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Titolo:
Neocortical abnormalities of [C-11]-flumazenil PET in mesial temporal lobeepilepsy
Autore:
Hammers, A; Koepp, M; Labbe, C; Brooks, DJ; Thom, M; Cunningham, VJ; Duncan, JS;
Indirizzi:
Natl Soc Epilepsy, London WC1N 3BG, England Natl Soc Epilepsy London England WC1N 3BG epsy, London WC1N 3BG, England Inst Neurol, London WC1N 3BG, England Inst Neurol London England WC1N 3BG nst Neurol, London WC1N 3BG, England Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC, Ctr Clin Sci, London, England Univ London Imperial Coll Sci Technol & Med London England don, England Inst Neurol, Dept Neuropathol, London WC1N 3BG, England Inst Neurol London England WC1N 3BG europathol, London WC1N 3BG, England
Titolo Testata:
NEUROLOGY
fascicolo: 7, volume: 56, anno: 2001,
pagine: 897 - 906
SICI:
0028-3878(20010410)56:7<897:NAO[PI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-11 FLUMAZENIL-PET; POSITRON-EMISSION-TOMOGRAPHY; HIPPOCAMPAL SCLEROSIS; BENZODIAZEPINE RECEPTORS; CORTICAL DYSPLASIA; PARTIAL SEIZURES; INCREASED NUMBER; MRI; BINDING; AUTORADIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Duncan, JS Natl Soc Epilepsy, 33 Queen Sq, London WC1N 3BG, England Natl Soc Epilepsy 33 Queen Sq London England WC1N 3BG England
Citazione:
A. Hammers et al., "Neocortical abnormalities of [C-11]-flumazenil PET in mesial temporal lobeepilepsy", NEUROLOGY, 56(7), 2001, pp. 897-906

Abstract

Objective: To characterize abnormalities in neocortical central benzodiazepine receptor (cBZR) binding in patients with mesial temporal lobe epilepsy(mTLE) with unilateral hippocampal sclerosis (HS) using [C-11]-flumazenil-(FMZ) PET and complementary voxel-based and quantitative volume-of-interest(VOI) methods. Methods: The authors studied 13 control subjects and 15 patients with refractory mTLE and unilateral HS with [C-11]-FMZ PET. Data werecorrected for partial volume effect in the interactively outlined hippocampus and in 28 cortical VOI using an individualized template. A voxel-based analysis was also performed using statistical parametric mapping (SPM). Results: Fourteen patients with mTLE had reduced [C-11]-FMZ volume distribution (V-d) in the hippocampus ipsilateral to the EEG focus, extending into theamygdala in four. Five patients showed additional significant neocortical abnormalities of [C-11]-FMZ binding: temporal neocortical increases (1), extratemporal decreases (2), extratemporal increases only (1), and temporal and extratemporal neocortical increases (I). Group VOI analysis revealed significant reductions only in the ipsilateral hippocampus. SPM showed decreased [C-11]-FMZ-V-d in the ipsilateral hippocampus in 13 of 15 patients, extending into the amygdala in eight. Five patients showed additional neocortical abnormalities: temporal neocortical increases only (3), extratemporal decreases (1), or both temporal neocortical and extratemporal decreases (I). Group analysis showed significant reductions in the ipsilateral hippocampusonly. Conclusions: A combination of VOI- and voxel-based analysis of [C-11]-FMZ PET detected extrahippocampal changes of cBZR binding in eight of 15 patients with mTLE due to HS. The finding of abnormalities in patients who were thought to have unilateral HS only based on MRI suggests that more widespread abnormalities are present in HS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:38:32