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Titolo:
Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
Autore:
Kocher, AA; Schuster, MD; Szabolcs, MJ; Takuma, S; Burkhoff, D; Wang, J; Homma, S; Edwards, NM; Itescu, S;
Indirizzi:
Columbia Univ, Dept Surg, New York, NY 10027 USA Columbia Univ New York NY USA 10027 iv, Dept Surg, New York, NY 10027 USA Columbia Univ, Dept Med, New York, NY USA Columbia Univ New York NY USAColumbia Univ, Dept Med, New York, NY USA Columbia Univ, Dept Pathol, New York, NY USA Columbia Univ New York NY USA lumbia Univ, Dept Pathol, New York, NY USA
Titolo Testata:
NATURE MEDICINE
fascicolo: 4, volume: 7, anno: 2001,
pagine: 430 - 436
SICI:
1078-8956(200104)7:4<430:NOIMBH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL PROGENITOR CELLS; TRANSCRIPTION FACTOR GATA-2; COLONY-STIMULATING FACTOR; MESENCHYMAL STEM-CELLS; ANGIOTENSIN-II; PLASMINOGEN-ACTIVATOR; THERAPEUTIC ANGIOGENESIS; HEMATOPOIETIC-CELLS; COMMON PRECURSOR; CORONARY-ARTERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Itescu, S Columbia Univ, Dept Surg, New York, NY 10027 USA Columbia Univ New York NY USA 10027 urg, New York, NY 10027 USA
Citazione:
A.A. Kocher et al., "Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function", NAT MED, 7(4), 2001, pp. 430-436

Abstract

Left ventricular remodeling is a major cause of progressive heart failure and death after myocardial infarction. Although neoangiogenesis within the infarcted tissue is an integral component of the remodeling process, the capillary network is unable to support the greater demands of the hypertrophied myocardium, resulting in progressive loss of viable tissue, infarct extension and fibrous replacement. Here we show that bone marrow from adult humans contains endothelial precursors with phenotypic and functional characteristics of embryonic hemangioblasts, and that these can be used to directlyinduce new blood vessel formation in the infarct-bed (vasculogenesis) and proliferation of preexisting vasculature (angiogenesis) after experimental myocardial infarction. The neoangiogenesis resulted in decreased apoptosis of hypertrophied myocytes in the peri-infarct region, long-term salvage andsurvival of viable myocardium, reduction in collagen deposition and sustained improvement in cardiac function. The use of cytokine-mobilized autologous human bone-marrow-derived angioblasts for revascularization of infarctedmyocardium (alone or in conjunction with currently used therapies) has thepotential to significantly reduce morbidity and mortality associated with left ventricular remodeling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:37:02