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Titolo:
Differentiation or leukemia: Is C/EBP alpha the answer?
Autore:
Hiebert, S;
Indirizzi:
Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 t Biochem, Nashville, TN 37232 USA
Titolo Testata:
NATURE MEDICINE
fascicolo: 4, volume: 7, anno: 2001,
pagine: 407 - 408
SICI:
1078-8956(200104)7:4<407:DOLICA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOID-LEUKEMIA; FUSION; T(8-21); TRANSCRIPTION; TRANSLOCATION; BINDING;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Hiebert, S Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Nashville, TN 37232 USA
Citazione:
S. Hiebert, "Differentiation or leukemia: Is C/EBP alpha the answer?", NAT MED, 7(4), 2001, pp. 407-408

Abstract

Acute myelogenous leukemias are caused by point mutations as well as several different types of chromosomal translocations, but little is known abouthow these genetic defects lead to disruptions in hematopoiesis and eventual leukemogenesis. Two recent studies suggest that the resulting mutant geneproducts can alter function of the transcription factor C/EBP alpha and tip the balance from differentiation toward cancer (pages 444-451).

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Documento generato il 05/04/20 alle ore 23:07:40