Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A point mutation in CD28 distinguishes proliferative signals from survivalsignals
Autore:
Okkenhaug, K; Wu, L; Garza, KM; La Rose, J; Khoo, W; Odermatt, B; Mak, TW; Ohashi, PS; Rottapel, R;
Indirizzi:
Univ Toronto, Dept Immunol, Toronto, ON M5S 1A2, Canada Univ Toronto Toronto ON Canada M5S 1A2 munol, Toronto, ON M5S 1A2, Canada Univ Toronto, Dept Med Biophys, Toronto, ON M5S 1A2, Canada Univ Toronto Toronto ON Canada M5S 1A2 ophys, Toronto, ON M5S 1A2, Canada Univ Toronto, Dept Med, Toronto, ON M5S 1A2, Canada Univ Toronto Toronto ON Canada M5S 1A2 t Med, Toronto, ON M5S 1A2, Canada Ontario Canc Inst, Toronto, ON M5G 2M9, Canada Ontario Canc Inst Toronto ON Canada M5G 2M9 , Toronto, ON M5G 2M9, Canada Princess Margaret Hosp, Toronto, ON M5G 2M9, Canada Princess Margaret Hosp Toronto ON Canada M5G 2M9 onto, ON M5G 2M9, Canada Univ Zurich, Inst Expt Immunol, CH-8091 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8091 unol, CH-8091 Zurich, Switzerland Amgen Inst, Toronto, ON, Canada Amgen Inst Toronto ON CanadaAmgen Inst, Toronto, ON, Canada St Michaels Hosp, Toronto, ON M5B 1W8, Canada St Michaels Hosp Toronto ONCanada M5B 1W8 p, Toronto, ON M5B 1W8, Canada
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 4, volume: 2, anno: 2001,
pagine: 325 - 332
SICI:
1529-2908(200104)2:4<325:APMICD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
JURKAT T-CELLS; PHOSPHATIDYLINOSITOL 3-KINASE ASSOCIATION; COSTIMULATORY RECEPTOR CD28; PROTEIN-TYROSINE KINASE; CD28-MEDIATED COSTIMULATION; CYTOPLASMIC DOMAIN; PHOSPHOINOSITIDE 3-KINASES; ADAPTER PROTEIN; IL-2 PRODUCTION; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Rottapel, R Univ Toronto, Dept Immunol, Toronto, ON M5S 1A2, Canada Univ Toronto Toronto ON Canada M5S 1A2 to, ON M5S 1A2, Canada
Citazione:
K. Okkenhaug et al., "A point mutation in CD28 distinguishes proliferative signals from survivalsignals", NAT IMMUNOL, 2(4), 2001, pp. 325-332

Abstract

Upon interaction with its ligand, B7, CD28 becomes phosphorylated on tyrosines, One tyrosine in particular (Y-170 in mouse CD28, Y-173 in human CD28)has received much attention. This is because it permits CD28 to recruit SH2-containing signaling molecules, including phosphoinositide 3 kinase, Grb2and Gads. Using mice we employed a transgenic approach to express a tyrosine-->phenylalanine mutant form of CD28 that uncouples these SH2-mediated interactions from CD28. The CD28 mutant is unable to up-regulate expression of the prosurvival protein Bcl-x(L), rendering the T cells move susceptible to radiation-induced death. Nonetheless, this mutated form of CD28 still prevents the induction of anergy and promotes T cell proliferation, interleukin 2 secretion and B cell help. Thus, we describe a single point mutation within the CD28 cytoplasmic domain that uncouples signals required for proliferation and survival.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/12/19 alle ore 01:37:09