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Titolo:
Gene regulation mediated by calcium signals in T lymphocytes
Autore:
Feske, S; Giltnane, J; Dolmetsch, R; Staudt, LM; Rao, A;
Indirizzi:
Harvard Univ, Sch Med, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ, Sch Med, Childrens Hosp, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hosp, Dept Pathol, Boston, MA 02115 USA NCI, Metab Branch, Div Clin Sci, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 ab Branch, Div Clin Sci, Bethesda, MD 20892 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 4, volume: 2, anno: 2001,
pagine: 316 - 324
SICI:
1529-2908(200104)2:4<316:GRMBCS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE COMBINED IMMUNODEFICIENCY; RESONANCE ENERGY-TRANSFER; STORE DEPLETION; INOSITOL TRISPHOSPHATE; INTRACELLULAR CALCIUM; TRANSCRIPTION FACTORS; PLASMA-MEMBRANE; CA2+ ENTRY; NF-AT; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Rao, A Harvard Univ, Sch Med, Ctr Blood Res, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 r Blood Res, Boston, MA 02115 USA
Citazione:
S. Feske et al., "Gene regulation mediated by calcium signals in T lymphocytes", NAT IMMUNOL, 2(4), 2001, pp. 316-324

Abstract

Modulation of many signaling pathways in antigen-stimulated T and B cells results in global changes in gene expression. Here we investigate the contribution of calcium signaling to gene expression in T cells using cell linesfrom two severe-combined immunodeficiency patients with several cytokine deficiencies and diminished activation of the transcription factor NFAT nuclear factor of activated T cells. These T cells show a strong defect in transmembrane calcium influx that is also apparent in their B cells and fibroblasts. DNA microarray analysis of calcium entry-deficient and control T cells shows that Ca2+ signals both activate and repress gene expression and arelargely transduced through the phosphatase calcineurin. We demonstrate an elaborate network of signaling pathways downstream of the T cell receptor, explaining the complexity of changes in gene expression during T cell activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:35:52