Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Repression of p15(INK4b) expression by Myc through association with Miz-1
Autore:
Staller, P; Peukert, K; Kiermaier, A; Seoane, J; Lukas, J; Karsunky, H; Moroy, T; Bartek, J; Massague, J; Hanel, F; Eilers, M;
Indirizzi:
Inst Mol Biol & Tumor Res, D-35033 Marburg, Germany Inst Mol Biol & Tumor Res Marburg Germany D-35033 35033 Marburg, Germany Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA Inst Canc Biol, DK-2100 Copenhagen, Denmark Inst Canc Biol Copenhagen Denmark DK-2100 l, DK-2100 Copenhagen, Denmark Univ Essen Gesamthsch, Inst Cell Biol, D-45122 Essen, Germany Univ Essen Gesamthsch Essen Germany D-45122 Biol, D-45122 Essen, Germany Hans Knoll Inst Naturstoff Forsch, D-07745 Jena, Germany Hans Knoll Inst Naturstoff Forsch Jena Germany D-07745 745 Jena, Germany
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 4, volume: 3, anno: 2001,
pagine: 392 - 399
SICI:
1465-7392(200104)3:4<392:ROPEBM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; CELL-CYCLE PROGRESSION; C-MYC; INHIBITOR P15(INK4B); GENE-TRANSFER; TARGET GENE; DNA-BINDING; TGF-BETA; IN-VIVO; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Eilers, M Inst Mol Biol & Tumor Res, Emil Mannkopff Str 2, D-35033 Marburg, Germany Inst Mol Biol & Tumor Res Emil Mannkopff Str 2 Marburg Germany D-35033
Citazione:
P. Staller et al., "Repression of p15(INK4b) expression by Myc through association with Miz-1", NAT CELL BI, 3(4), 2001, pp. 392-399

Abstract

Deregulated expression of c-myc can induce cell proliferation in established cell lines and in primary mouse embryonic fibroblasts (MEFs), through a combination of both transcriptional activation and repression by Myc. Here we show that a Myc-associated transcription factor, Miz-1, arrests cells inG1 phase and inhibits cyclin D-associated kinase activity. Miz-1 upregulates expression of the cyclin-dependent kinases (CDK) inhibitor p15(INK4b) bybinding to the initiator element of the p15(INK4b) promoter. Myc and Max form a complex with Miz-1 at the p15 initiator and inhibit transcriptional activation by Miz-1. Expression of Myc in primary cells inhibits the accumulation of p15(INK4b) that is associated with cellular senescence; converselydeletion of c-myc in an established cell line activates p15(INK4b) expression. Alleles of c-myc that are unable to bind to Miz-1 fail to inhibit accumulation of p15(INK4b) messenger RNA in primary cells and are, as a consequence, deficient in immortalization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 14:11:16