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Titolo:
Spatial regulation of the exocyst complex by Rho1 GTPase
Autore:
Guo, W; Tamanoi, F; Novick, P;
Indirizzi:
Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06520 USA Yale Univ NewHaven CT USA 06520 Dept Cell Biol, New Haven, CT 06520 USA Univ Calif Los Angeles, Inst Mol Biol, Dept Microbiol & Mol Genet, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 4, volume: 3, anno: 2001,
pagine: 353 - 360
SICI:
1465-7392(200104)3:4<353:SROTEC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL CONTACTS; PROTEIN-KINASE-C; CLASS-V MYOSIN; SACCHAROMYCES-CEREVISIAE; BUDDING YEAST; ACTIN CYTOSKELETON; BINDING PROTEIN; POLARIZED SECRETION; VESICULAR TRANSPORT; SEC6/8 COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Novick, P Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06520 USA YaleUniv New Haven CT USA 06520 Biol, New Haven, CT 06520 USA
Citazione:
W. Guo et al., "Spatial regulation of the exocyst complex by Rho1 GTPase", NAT CELL BI, 3(4), 2001, pp. 353-360

Abstract

Spatial regulation of membrane traffic is fundamental to many biological processes, including epithelial cell polarization and neuronal synaptogenesis. The multiprotein exocyst complex is localized to sites of polarized exocytosis, and is required for vesicle targeting and docking at specific domains of the plasma membrane. One component of the complex, Sec3, is thought to be a spatial landmark for polarized exocytosis, We have searched for proteins that regulate the polarized localization of the exocyst in the buddingyeast Saccharomyces cerevisiae. Here we report that certain rho1 mutant alleles specifically affect the localization of the exocyst proteins. Sec3 interacts directly with Rho1 in its GTP-bound form, and functional Rho1 is needed both to establish and to maintain the polarized localization of Sec3, Sec3 is not the only mediator of the effect of Rho1 on the exocyst, becausesome members of the complex are correctly targeted independently of the interaction between Rho1 and Sec3. These results reveal the action of parallel pathways for the polarized localization of the exocytic machinery, both of which are under the control of Rho1, a master regulator of cell polarity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:57:47