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Titolo:
Pathways to neuronal injury and apoptosis in HIV-associated dementia
Autore:
Kaul, M; Garden, GA; Lipton, SA;
Indirizzi:
Burnham Inst, Ctr Neurosci & Aging Res, La Jolla, CA 92037 USA Burnham Inst La Jolla CA USA 92037 ci & Aging Res, La Jolla, CA 92037 USA Univ Washington, Dept Neurol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Neurol, Seattle, WA 98195 USA
Titolo Testata:
NATURE
fascicolo: 6831, volume: 410, anno: 2001,
pagine: 988 - 994
SICI:
0028-0836(20010419)410:6831<988:PTNIAA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; METHYL-D-ASPARTATE; NEUROCOGNITIVELY IMPAIRED INDIVIDUALS; CULTURED HIPPOCAMPAL-NEURONS; PLATELET-ACTIVATING-FACTOR; CHEMOKINE RECEPTOR CXCR4; BLOOD-BRAIN-BARRIER; CEREBROSPINAL-FLUID;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Kaul, M Burnham Inst, Ctr Neurosci & Aging Res, 10901 N Torrey Pines Rd, La Jolla,CA 92037 USA Burnham Inst 10901 N Torrey Pines Rd La Jolla CA USA 92037 037 USA
Citazione:
M. Kaul et al., "Pathways to neuronal injury and apoptosis in HIV-associated dementia", NATURE, 410(6831), 2001, pp. 988-994

Abstract

Human immunodeficiency virus-1 (HIV-1) can induce dementia with alarming occurrence worldwide. The mechanism remains poorly understood, but discoveryin brain of HIV-1-binding sites (chemokine receptors) provides new insights. HIV-1 infects macrophages and microglia, but not neurons, although neurons are injured and die by apoptosis. The predominant pathway to neuronal injury is indirect through release of macrophage, microglial and astrocyte toxins, although direct injury by viral proteins might also contribute. Thesetoxins overstimulate neurons, resulting in the formation of free radicals and excitotoxicity, similar to other neurodegenerative diseases. Recent advances in understanding the signalling pathways mediating these events offerhope for therapeutic intervention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:25:02