Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mutation spectrum of o-aminoazotoluene in the cII gene of lambda/lacZ transgenic mice (Muta (TM) Mouse)
Autore:
Kohara, A; Suzuki, T; Honma, M; Hirano, N; Ohsawa, K; Ohwada, T; Hayashi, M;
Indirizzi:
Natl Inst Hlth Sci, Div Genet & Mutagenesis, Setagaya Ku, Tokyo 1588501, Japan Natl Inst Hlth Sci Tokyo Japan 1588501 Setagaya Ku, Tokyo 1588501, Japan Nagoya City Univ, Fac Pharmaceut Sci, Div Pathol, Mizuho Ku, Nagoya, Aichi4678603, Japan Nagoya City Univ Nagoya Aichi Japan 4678603 , Nagoya, Aichi4678603, Japan Taisho Pharmaceut Co Ltd, Pharmaceut Res Labs, Toxicol Lab, Ohmiya, Saitama 3308530, Japan Taisho Pharmaceut Co Ltd Ohmiya Saitama Japan 3308530 tama 3308530, Japan
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 1-2, volume: 491, anno: 2001,
pagine: 211 - 220
SICI:
1383-5718(20010405)491:1-2<211:MSOOIT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIG BLUE(R) MICE; VIVO LACI MUTATIONS; HUMAN HPRT GENE; HUMAN P53 GENE; MUTANT FREQUENCIES; MOLECULAR ANALYSIS; 7,12-DIMETHYLBENZANTHRACENE; RATS; BENZOPYRENE; GENOTOXICITY;
Keywords:
o-aminoazotoluene; cII; Muta (TM) Mouse; mutation spectrum; G : C to T : A transversion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, T Natl Inst Hlth Sci, Div Genet & Mutagenesis, Setagaya Ku, 1-18-1Kamiyoga,Tokyo 1588501, Japan Natl Inst Hlth Sci 1-18-1 Kamiyoga Tokyo Japan 1588501 1, Japan
Citazione:
A. Kohara et al., "Mutation spectrum of o-aminoazotoluene in the cII gene of lambda/lacZ transgenic mice (Muta (TM) Mouse)", MUT RES-GTE, 491(1-2), 2001, pp. 211-220

Abstract

The o-aminoazotoluene (AAT) has been evaluated as a possible human carcinogen by the International Agency for Research on Cancer. In rodents, it is carcinogenic mainly in the liver, and also in lung following long term administration. We previously examined in lambda/lacZ transgenic mice for the induction of lacZ mutations in liver, lung, urinary bladder, colon, kidney, bone marrow, and testis. AAT induced gene mutations strongly in the liver and colon. In the present report, we reveal the molecular nature of mutationsinduced by AAT in the lambda cII gene (the cbl gene, a phenotypically selectable marker in the lambda transgene, has 294 bp, which makes it easier tosequence than the original target, the 3 kb lacZ gene). The cII mutant frequency in liver and colon was five and nine times higher, respectively, in AAT-treated mice than in control mice. Sequence analysis revealed that AAT induced G:C to T:A transversions, whereas spontaneous mutations consisted primarily of G:C to A:T transitions at CpG sites. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:09:02