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Titolo:
Influence of smokeless tobacco exposure on detoxification status and chromosomal damage in male and female habitues
Autore:
Mahimkar, MB; Buch, SC; Samant, TA; Kapoor, MD; Bhisey, RA;
Indirizzi:
Tata Mem Ctr, Canc Res Inst, Div Carcinogenesis, Parel 400012, Mumbai, India Tata Mem Ctr Parel Mumbai India 400012 nesis, Parel 400012, Mumbai, India
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 1-2, volume: 491, anno: 2001,
pagine: 111 - 117
SICI:
1383-5718(20010405)491:1-2<111:IOSTEO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE; CHEWERS; SALIVA; N'-NITROSONORNICOTINE; GENOTOXICITY; NITROSAMINES; TRANSFERASES; PRODUCTS; CANCER; USERS;
Keywords:
tobacco; chromosomal damage; GSH/GST system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Bhisey, RA Tata Mem Ctr, Canc Res Inst, Div Carcinogenesis, Parel 400012, Mumbai, India Tata Mem Ctr Parel Mumbai India 400012 l 400012, Mumbai, India
Citazione:
M.B. Mahimkar et al., "Influence of smokeless tobacco exposure on detoxification status and chromosomal damage in male and female habitues", MUT RES-GTE, 491(1-2), 2001, pp. 111-117

Abstract

In India, a large number of tobacco chewers and masheri users are chronically exposed to tobacco genotoxicants. Detoxification processes involving cellular glutathione (GSH) and glutathione S-transferases (GST) determine theoutcome of exposure to environmental mutagens including those present in tobacco. Hence, in this study, GSH levels, GST activity, GSTM1 genotype and cytogenetic damage were determined using lymphocytes from 114 smokeless tobacco habitues and controls. The study groups comprised of male tobacco chewers, female masheri users, and age- and sex-matched controls. Irrespective of the tobacco habit, GSH levels and GST activity were higher in females than in males. In both the groups of habitues, GSH levels were similar to those in controls, while a significant reduction in GST activity was observed in tobacco chewers only. The frequency of cytogenetic alterations was significantly elevated in both the groups of habitues with respect to controls. However, break-type aberrations were more frequent in tobacco chewers whilegaps were commonly observed in masheri users. Differences in the nature ofchromosomal alterations in the two groups of habitues appeared to be related to variation in total tobacco exposure and gender-related differences inthe efficacy of the GSH/GST detoxification system. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:30:45