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Titolo:
Chromosome painting for cytogenetic monitoring of occupationally exposed and non-exposed groups of human individuals
Autore:
Verdorfer, I; Neubauer, S; Letzel, S; Angerer, J; Arutyunyan, R; Martus, P; Wucherer, M; Gebhart, E;
Indirizzi:
Univ Erlangen Nurnberg, Inst Human Genet, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany Univ Erlangen Nurnberg, Clin Radiotherapy, Erlangen, Germany Univ ErlangenNurnberg Erlangen Germany Radiotherapy, Erlangen, Germany Univ Erlangen Nurnberg, Inst Occupat Social & Environm Med, Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany Environm Med, Erlangen, Germany Yerevan State Univ, Dept Genet, Yerevan 375049, Armenia Yerevan State Univ Yerevan Armenia 375049 Genet, Yerevan 375049, Armenia Univ Mainz, Inst Med Stat & Documentat, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 Stat & Documentat, D-6500 Mainz, Germany Clinicum City Nuremberg, Dept Nucl Med, Nuremberg, Germany Clinicum City Nuremberg Nuremberg Germany Nucl Med, Nuremberg, Germany
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 1-2, volume: 491, anno: 2001,
pagine: 97 - 109
SICI:
1383-5718(20010405)491:1-2<97:CPFCMO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; INDUCED STRUCTURAL-ABERRATIONS; HUMAN PERIPHERAL LYMPHOCYTES; CANCER-PATIENTS; EXCHANGE ABERRATIONS; RADIATION EXPOSURE; IONIZING-RADIATION; EQUAL INDUCTION; DAMAGE; FISH;
Keywords:
chromosome painting; human population monitoring; hybridization technique;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Gebhart, E Univ Erlangen Nurnberg, Inst Human Genet, Schwabachanlage 10, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Schwabachanlage 10 Erlangen Germany D-91054
Citazione:
I. Verdorfer et al., "Chromosome painting for cytogenetic monitoring of occupationally exposed and non-exposed groups of human individuals", MUT RES-GTE, 491(1-2), 2001, pp. 97-109

Abstract

The suitability of a three-color fluorescence in situ suppression hybridization technique was examined for monitoring five different groups of individuals: 30 occupied in radiology, 26 occupied in nuclear medicine or radiation physics, 32 patients with breast cancer, 26 occupied with military wastedisposal, all presumably exposed to low doses of radiation or chemical mutagens and a non-exposed control group (N = 29). The average frequency of breaks constituting the various aberrations did not significantly differ between the groups of medical radiation appliers and the control group. However, breast tumor patients and military waste disposers, as groups, showed a higher aberration rate than did healthy controls. Stable rearrangements mainly characterized the groups of controls, tumor patients, and radiation appliers, while a higher proportion of unstable aberrations was found in the chemically exposed individuals. Individuals with an increased frequency of aberrations could be detected within each examined group, which clearly determined the average values of the whole group. With respect to interchromosomal distribution of the breakpoints constituting the found aberrations and the involvement of the labeled chromosomes in rearrangements, the observed values were very close to the expected ones in the controls. A rather similar trend of deviations from expectation was observed in all other groups. Chromosome 4 was slightly over-affected, while chromosome 2 was slightly underrepresented in all analyzed groups (except tumor patients). Rearrangementsof the labeled chromosomes with the unlabeled ones exceeded expectation. In conclusion, chromosome painting if included in further attempts of human population monitoring will broaden the basis of argumentation with respect to health risks introduced by mutagen exposure. (C) 2001 Elsevier Science B. V. All rights reserved.

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Documento generato il 06/04/20 alle ore 01:59:27