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Titolo:
Fibronectin fragment CH-296 inhibits apoptosis and enhances ex vivo gene transfer by murine retrovirus and human lentivirus vectors independent of viral tropism in nonhuman primate CD34(+) cells
Autore:
Donahue, RE; Sorrentino, BP; Hawley, RG; An, DS; Chen, ISY; Wersto, RP;
Indirizzi:
NIA, Ctr Gerontol Res, Flow Cytometry Unit, NIH, Baltimore, MD 21224 USA NIA Baltimore MD USA 21224 w Cytometry Unit, NIH, Baltimore, MD 21224 USA Univ Calif Los Angeles, Sch Med, AIDS Inst, Los Angeles, CA 90095 USA UnivCalif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Amer Red Cross, Jerome H Holland Lab, Rockville, MD 20855 USA Amer Red Cross Rockville MD USA 20855 olland Lab, Rockville, MD 20855 USA St Jude Childrens Res Hosp, Memphis, TN 38105 USA St Jude Childrens Res Hosp Memphis TN USA 38105 sp, Memphis, TN 38105 USA NHLBI, Hematol Branch, NIH, Bethesda, MD 21892 USA NHLBI Bethesda MD USA 21892 , Hematol Branch, NIH, Bethesda, MD 21892 USA
Titolo Testata:
MOLECULAR THERAPY
fascicolo: 3, volume: 3, anno: 2001,
pagine: 359 - 367
SICI:
1525-0016(200103)3:3<359:FFCIAA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC STEM-CELLS; APE LEUKEMIA-VIRUS; GREEN FLUORESCENT PROTEIN; COLONY-STIMULATING FACTOR; BONE-MARROW; PERIPHERAL-BLOOD; PROGENITOR CELLS; IN-VIVO; EXTRACELLULAR-MATRIX; REPOPULATING CELLS;
Keywords:
CH-296; gene therapy; hematopoietic stem cells; retrovirus; lentivirus; cell cycle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Wersto, RP NIA, Ctr Gerontol Res, Flow Cytometry Unit, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224 USA NIA 5600 Nathan Shock Dr Baltimore MD USA 21224 e, MD 21224 USA
Citazione:
R.E. Donahue et al., "Fibronectin fragment CH-296 inhibits apoptosis and enhances ex vivo gene transfer by murine retrovirus and human lentivirus vectors independent of viral tropism in nonhuman primate CD34(+) cells", MOL THER, 3(3), 2001, pp. 359-367

Abstract

The fibronectin fragment CH-296 improved gene transfer to cytokine-mobilized nonhuman primate CD34(+) cells irrespective of tropism to the MoMLV, GaLV, and VSV-C envelope proteins using murine stem cell virus (MSCV) and human immunodeficiency virus-1 (HIV-1)-based retrovirus vectors. For the HIV-1 lentivirus vector, CH-296 enhanced gene transfer in the absence of added hematopoietic growth factors necessary for ex vivo stem cell expansion. In the presence of CH-296, apoptosis of CD34+ cells was inhibited, and in mobilized peripheral blood CD34+ cells, cell division was stimulated as measured by cell history/tracking experiments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:21:43