Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Immunohistochemical localization of insulin-like growth factors I and II at the primary implantation site in the Rhesus monkey
Autore:
Dhara, S; Lalitkumar, PGL; Sengupta, J; Ghosh, D;
Indirizzi:
All India Inst Med Sci, Dept Physiol, New Delhi 110029, India All India Inst Med Sci New Delhi India 110029 l, New Delhi 110029, India
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 4, volume: 7, anno: 2001,
pagine: 365 - 371
SICI:
1360-9947(200104)7:4<365:ILOIGF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR BINDING PROTEIN-1; SYSTEM GENE-EXPRESSION; TROPHOBLASTIC INVASION; FACTOR IGF; PLACENTAL DEVELOPMENT; CELL-MIGRATION; RAT UTERUS; DIFFERENTIATION; PROGESTERONE; RECEPTOR;
Keywords:
cytotrophoblast; endometrium; implantation; insulin-like growth factors; syncytiotrophoblast;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Ghosh, D All India Inst Med Sci, Dept Physiol, New Delhi 110029, India AllIndia Inst Med Sci New Delhi India 110029 lhi 110029, India
Citazione:
S. Dhara et al., "Immunohistochemical localization of insulin-like growth factors I and II at the primary implantation site in the Rhesus monkey", MOL HUM REP, 7(4), 2001, pp. 365-371

Abstract

There are various cellular mediators which can affect the process of blastocyst implantation by regulating the proliferation and differentiation of conceptus and maternal endometrial cells. Insulin-like growth factors I (IGF-I) and II (IGF-II) are potent mitogenic and differentiation-promoting growth factors. However, the role of IGF peptides at implantation in primate species is not well understood. The objective of the present study was to immunohistochemically localize IGF-I and IGF-II peptides in trophoblast cells and maternal endometrial cells during lacunar and villous stages of placentation in the Rhesus monkey. Female animals (n = 10) were laparotomized on estimated days 13-16 after fertilization to collect primary implantation sites which were subjected to immunohistochemical staining for IGF-I and IGF-II peptides. Cell-type specificity for IGF-I and IGF-II was evident with a very low level of IGF-I peptide immunolocalized in trophoblast cells lining lacunae, and primary and secondary villi, while moderate to high amounts ofIGF-II peptide were detected in lamellar syncytiotrophoblast cells lining lacunae, early villi and cell columns, as well as in migrating trophoblast cells in the extravillous compartment and in endovascular trophoblast cells. The observed presence of IGF-II peptide in differentiated lamellar syncytiotrophoblast cells during the very early stages of implantation and placentation in the Rhesus monkey may be important in their transition to this differentiated cell population. Maternal endometrial cells showed similar distribution profiles for IGF-I and IGF-II, In conclusion, we report differential distribution of IGF-I and IGF-II peptides in trophoblast cell populations at the fete-maternal interface during lacunar and villous stages of gestation in the Rhesus monkey.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:33:26