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Titolo:
The balance between MMP-9 and MMP-2 and their tissue inhibitor (TIMP)-1 inluteinized granulosa cells: comparison between women with PCOS and normal ovulatory women
Autore:
Shalev, E; Goldman, S; Ben-Shlomo, I;
Indirizzi:
HaEmek Med Ctr, Dept Obstet & Gynecol, Lab Res Reprod Sci, IL-18101 Afula,Israel HaEmek Med Ctr Afula Israel IL-18101 s Reprod Sci, IL-18101 Afula,Israel Technion Israel Inst Technol, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel Technion Israel Inst Technol Haifa Israel IL-31096 L-31096 Haifa, Israel
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 4, volume: 7, anno: 2001,
pagine: 325 - 331
SICI:
1360-9947(200104)7:4<325:TBBMAM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYSTIC-OVARY-SYNDROME; MATRIX-METALLOPROTEINASE; GENE-EXPRESSION; IN-VITRO; PHYSIOLOGICAL SIGNALS; GELATINASE-A; GROWTH; IDENTIFICATION; FOLLICLES; DISEASE;
Keywords:
luteinized granulosa cells; MMP; polycystic ovarian syndrome; TIMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Shalev, E HaEmek Med Ctr, Dept Obstet & Gynecol, Lab Res Reprod Sci, IL-18101 Afula,Israel HaEmek Med Ctr Afula Israel IL-18101 ci, IL-18101 Afula,Israel
Citazione:
E. Shalev et al., "The balance between MMP-9 and MMP-2 and their tissue inhibitor (TIMP)-1 inluteinized granulosa cells: comparison between women with PCOS and normal ovulatory women", MOL HUM REP, 7(4), 2001, pp. 325-331

Abstract

Polycystic ovarian syndrome (PCOS) involves follicular atresia, formation of multiple ovarian cysts and is frequently associated with a higher abortion rate. Follicular development, ovulation, formation of corpus luteum and its regression involve extensive tissue remodelling. Mammalian ovaries express a number of matrix metalloproteinases (MMP) and their tissue inhibitors(TIMP). We assessed the differences in production of MMP-2, MMP-9 and TIMP-1 by cultured luteinized granulosa cells from women with PCOS and normal ovulatory women after ovarian stimulation for IVF treatment. In follicular fluid from women with PCOS, levels of MMP-9 and MMP-2 were higher than the normal group, as was the basal production of these proteins by cultured cells. Basal production of TIMP-1 by cultured cells was not different between PCOS and normal groups. A time-dependent increase in the production of MMP-9was observed in cells from both normal and PCOS women, although the increase was more pronounced in the latter Thus the MMP-TIMP balance is shifted toward greater MMP activity in luteinized granulosa cells from women with PCOS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:55:15