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Titolo:
Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway
Autore:
Lamaze, C; Dujeancourt, A; Baba, T; Lo, CG; Benmerah, A; Dautry-Varsat, A;
Indirizzi:
Inst Pasteur, Unite Biol Interact Cellulaires, URA CNRS 1960, F-75724 Paris 15, France Inst Pasteur Paris France 15 es, URA CNRS 1960, F-75724 Paris 15, France Yamanashi Med Univ, Dept Anat, Yamanashi, Japan Yamanashi Med Univ Yamanashi Japan ed Univ, Dept Anat, Yamanashi, Japan
Titolo Testata:
MOLECULAR CELL
fascicolo: 3, volume: 7, anno: 2001,
pagine: 661 - 671
SICI:
1097-2765(200103)7:3<661:I2RADM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GPI-ANCHORED PROTEINS; COATED VESICLE FORMATION; FC-EPSILON-RI; PLASMA-MEMBRANE; CELL-SURFACE; MEDIATED ENDOCYTOSIS; CROSS-LINKING; IL-2 RECEPTOR; T-LYMPHOCYTES; CHOLERA-TOXIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Lamaze, C Inst Pasteur, Unite Biol Interact Cellulaires, URA CNRS 1960, 25Rue Dr Roux, F-75724 Paris 15, France Inst Pasteur 25 Rue Dr Roux Paris France 15 24 Paris 15, France
Citazione:
C. Lamaze et al., "Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway", MOL CELL, 7(3), 2001, pp. 661-671

Abstract

Clathrin-dependent endocytosis has long been presented as the only efficient mechanism by which transmembrane receptors are internalized. We selectively blocked this process using dominant-negative mutants of Eps15 and showed that clathrin-mediated endocytosis of transferrin was inhibited, while endocytosis of interleukin 2 (IL2) receptors proceeded normally. Ultrastructural and biochemical experiments showed that clathrin-independent endocytosis of IL2 receptors exists constitutively in lymphocytes and is coupled to their association with detergent-resistant membrane domains. Finally, clathrin-independent endocytosis requires dynamin and is specifically regulated by Rho family GTPases. These results define novel properties of receptor-mediated endocytosis and establish that the IL2 receptor is efficiently internalized through this clathrin-independent pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:11:32