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Titolo:
Development of scoliosis following pinealectomy in young chickens is not the result of an artifact of the surgical procedure
Autore:
Beuerlein, M; Wang, X; Moreau, M; Raso, J; Mahood, J; Bagnall, K;
Indirizzi:
Univ Alberta, Div Anat, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 nat, Edmonton, AB T6G 2H7, Canada Univ Alberta, Dept Surg, Edmonton, AB T6G 2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 urg, Edmonton, AB T6G 2H7, Canada Glenrose Rehabil Hosp, Edmonton, AB, Canada Glenrose Rehabil Hosp Edmonton AB Canada abil Hosp, Edmonton, AB, Canada
Titolo Testata:
MICROSCOPY RESEARCH AND TECHNIQUE
fascicolo: 1, volume: 53, anno: 2001,
pagine: 81 - 86
SICI:
1059-910X(20010401)53:1<81:DOSFPI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADOLESCENT IDIOPATHIC SCOLIOSIS; SERUM MELATONIN LEVELS; PATHOGENESIS; GROWTH; GIRLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Bagnall, K Univ Alberta, Div Anat, 5-28 Med Sci Bldg, Edmonton, AB T6G 2H7, Canada Univ Alberta 5-28 Med Sci Bldg Edmonton AB Canada T6G 2H7 anada
Citazione:
M. Beuerlein et al., "Development of scoliosis following pinealectomy in young chickens is not the result of an artifact of the surgical procedure", MICROSC RES, 53(1), 2001, pp. 81-86

Abstract

Pinealectomy in young chickens consistently results in scoliosis, which has many characteristics similar to those seen in adolescent idiopathic scoliosis. The mechanism underlying this phenomenon remains a mystery and it is not yet entirely clear whether some unidentified aspect of the extensive surgery is the major factor rather than the removal of the pineal gland. Fourdifferent types of pinealectomy surgery were performed on young chickens as well as deliberate damage to the cerebral cortex which simulated the extreme of any accidental damage that might occur during surgery. Scoliosis wasassessed from weekly radiographs. No differences in incidence of scoliosis, degree of severity, or pattern of curve development were observed for anyof the experimental groups when compared with controls. In all groups approximately 55% of the chickens developed scoliosis that progressed rapidly. Different pinealectomy procedures and deliberate damage to the cerebral cortex produce scoliosis in young chickens with the same incidence and characteristics. This suggests strongly that the mechanism behind the phenomenon is due to the removal of the pineal gland and not some artifact of the extensive surgery. The pinealectomy model in young chickens is proving to be a good model for studying AIS in humans. An understanding of the mechanism underlying this phenomenon has the potential to provide further insights into the etiology of AIS and can lead to the development of novel treatment methods. Microsc. Res. Tech. 53: 81-86, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 00:25:35