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Titolo:
Hormonal alterations on young morbid obese women
Autore:
Vila, R; Gutierrez, R; Granada, ML; Masanes, RM; Grasa, MD; Lopez, JAF; Remesar, X; Formiguera, X; Foz, M; Alemany, M;
Indirizzi:
Univ Barcelona, Fac Biol, Ctr Recerca Nutr & Ciencia Aliments, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 liments, E-08028 Barcelona, Spain Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Med Interna Serv, E-08193 Barcelona, Spain Univ Autonoma Barcelona Barcelona Spain E-08193 E-08193 Barcelona, Spain Univ Autonoma Barcelona, Hosp Germans Trias & Pujol, Serv Bioquim, E-08193Barcelona, Spain Univ Autonoma Barcelona Barcelona Spain E-08193 E-08193Barcelona, Spain
Titolo Testata:
MEDICINA CLINICA
fascicolo: 9, volume: 116, anno: 2001,
pagine: 321 - 323
SICI:
0025-7753(20010310)116:9<321:HAOYMO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
SPA
Soggetto:
CORTICOSTEROID-BINDING GLOBULIN; INSULIN-RESISTANCE; OLEOYL-ESTRONE; BODY-FAT; LEPTIN CONCENTRATIONS; CORTISOL SECRETION; ABDOMINAL OBESITY; NORMAL-WEIGHT; ESTER LEVELS; HUMANS;
Keywords:
young obese women; insulin; leptin; acylestrone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Alemany, M Univ Barcelona, Fac Biol, Ctr Recerca Nutr & Ciencia Aliments, Avda Diagonal 645, E-08028 Barcelona, Spain Univ Barcelona Avda Diagonal 645 Barcelona Spain E-08028 Spain
Citazione:
R. Vila et al., "Hormonal alterations on young morbid obese women", MED CLIN, 116(9), 2001, pp. 321-323

Abstract

BACKGROUND: Human obesity is a widespread disease with considerable variability as to its severity, metabolic and endocrine manifestations and etiology. In the present study we have determined whether the alterations of uncomplicated severe obesity in adult young women affect with different intensity the circulating levels of hormones that have been postulated to intervene in the development and maintenance of obesity. SUBJECTS AND METHOD: Age-matched 20 mobidly obese (BMI 52.6 [8.3 SD] kg/m(2)) 10 normal-weight control women (BMI 19.9 [2.1 SD] kg/m(2)) were studiedand determined the basal circulating levels of hormones and proteins related with the control of body weight. RESULTS: Obese women showed higher concentrations of insulin and leptin, and lower of cortisol and cortisol-binding globulin (CBG). No significant differences were appreciated for free thyroxine, TSH, free and acylestrone and dehydroepiandrosterone-sulphate. CONCLUSIONS: The results suggest that morbid obesity implies the alteration of the main hormonal systems controlling the availability of energy and the response to external challenges, with the noteworthy exception of the thyroid. There were clear alterations of insulin and leptin, but cortisol changes could be more related to factors other than obesity. The lower than expected levels of acylestrone point to a possible deficit of this ponderostat signal in obese women. The relatively young age of the women in the studymay account for the relative shallowness of the hormonal changes observed.

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Documento generato il 11/07/20 alle ore 14:37:36