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Titolo:
Proteoglycans in the nervous system - the quest for functional roles in vivo
Autore:
Hartmann, U; Maurer, P;
Indirizzi:
Univ Cologne, Fac Med, Inst Biochem, Cologne, Germany Univ Cologne Cologne Germany e, Fac Med, Inst Biochem, Cologne, Germany
Titolo Testata:
MATRIX BIOLOGY
fascicolo: 1, volume: 20, anno: 2001,
pagine: 23 - 35
SICI:
0945-053X(200102)20:1<23:PITNS->2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHONDROITIN-SULFATE PROTEOGLYCAN; AMYLOID PRECURSOR PROTEIN; BEHMEL OVERGROWTH SYNDROME; NEURITE OUTGROWTH; CELL-SURFACE; TARGETED DISRUPTION; ALZHEIMERS-DISEASE; HYALURONAN-BINDING; POTENTIAL ROLE; CORE PROTEINS;
Keywords:
proteoglycan; glycosaminoglycan; chondroitin sulfate; dermatan sulfate; heparan sulfate; keratan sulfate; nervous system; development; knockout mice;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Hartmann, U Univ Cologne, Fac Med, Inst Biochem, Cologne, Germany Univ Cologne Cologne Germany Inst Biochem, Cologne, Germany
Citazione:
U. Hartmann e P. Maurer, "Proteoglycans in the nervous system - the quest for functional roles in vivo", MATRIX BIOL, 20(1), 2001, pp. 23-35

Abstract

Large numbers of different proteoglycans are expressed in tightly regulated spatio-temporal patterns by both the nerve cells (neurons) and the supporting glial cells of the nervous system. Several of these proteoglycans havebeen shown by studies in vitro to affect the migration of neural precursorcells, the elongation and pathfinding of neurites and the formation and stabilization of synapses. Such processes are important for the accurate wiring of the nervous system, and so it has been postulated that proteoglycans play an essential role during neural development. However, with few exceptions, the phenotypes of null mutations in mice and some human genetic diseases have provided little support for this view. Here we will review recent data from both in vitro and in vivo studies analyzing the function of proteoglycans in the nervous system in order to provide possible explanations fortheir apparent lack of function. (C) 2001 Elsevier Science B.V./International Society of Matrix Biology. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:22:02