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Titolo:
Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or alpha-linolenic acids
Autore:
Watkins, SM; Lin, TY; Davis, RM; Ching, JR; DePeters, EJ; Halpern, GM; Walzem, RL; German, JB;
Indirizzi:
Univ Calif Davis, Dept Food Sci & Technol, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 od Sci & Technol, Davis, CA 95616 USA FAME Analyt, W Sacramento, CA 95691 USA FAME Analyt W Sacramento CA USA 95691 Analyt, W Sacramento, CA 95691 USA Univ Calif Davis, Dept Anim Sci, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 s, Dept Anim Sci, Davis, CA 95616 USA Univ Calif Davis, Sch Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 f Davis, Sch Med, Davis, CA 95616 USA Texas A&M Univ, Fac Nutr, Dept Poultry Sci, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 ry Sci, College Stn, TX 77843 USA
Titolo Testata:
LIPIDS
fascicolo: 3, volume: 36, anno: 2001,
pagine: 247 - 254
SICI:
0024-4201(200103)36:3<247:UPMIMH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYUNSATURATED FATTY-ACIDS; RAT-LIVER MITOCHONDRIA; FISH-OIL; EICOSAPENTAENOIC ACID; VENTRICULAR-FIBRILLATION; MYOCARDIAL DYSFUNCTION; CARDIAC PHOSPHOLIPIDS; BIOSYNTHESIS; CARDIOLIPIN; REPERFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Watkins, SM Univ Calif Davis, Dept Food Sci & Technol, 1 Shields Ave, Davis, CA 95616 USA Univ Calif Davis 1 Shields Ave Davis CA USA 95616 CA 95616 USA
Citazione:
S.M. Watkins et al., "Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or alpha-linolenic acids", LIPIDS, 36(3), 2001, pp. 247-254

Abstract

Diet and fatty acid metabolism interact in yet unknown ways to modulate membrane fatty acid composition and certain cellular functions. For example, dietary precursors or metabolic products of n-3 fatty acid metabolism differ in their ability to modify specific membrane components. In the present study, the effect of dietary 22:6n-3 or its metabolic precursor, 18:3n-3, onthe selective accumulation of 22:6n-3 by heal? was investigated. The mass and fatty acid compositions of individual phospholipids (PL) in heart and liver were quantified in mice fed either 22:6n-3 (from crocodile oil) or 18:3n-3 (from soybean oil) for 13 wk. This study was conducted to determine iithe selective accumulation of 22:6n-3 in heart was due to the incorporation of 22:6n-3 into cardiolipin (CL), a PL most prevalent in heart and known to accumulate 22:6n-3. Although heart was significantly enriched with 22:6n-3 relative to liver, the accumulation of 22:6n-3 by CL in heart could not quantitatively account for this difference. CL from heart did accumulate 22:6n-3, bur only in mice fed preformed 22:6n-3. Diets rich in non-22:6n-3 fatty acids result in a fatty acid composition of phosphatidylcholine (PC) inheart that is unusually enriched with 22:6n-3. In this study, the mass of PC in heart was positively correlated with the enrichment of 22:6n-3 into PC. The increased mass of PC was coincident With a decrease in the mass of phosphatidylethanolamine, suggesting that 22:6n-3 induced PC synthesis by increasing phosphatidylethanolamine-N-methyltransferase activity in the heart.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:29:06