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Titolo:
Peripheral differential leukocyte counts in humans vary with hyperlipidemia, smoking, and body mass index
Autore:
Huang, ZS; Chien, KL; Yang, CY; Tsai, KS; Wang, CH;
Indirizzi:
Natl Taiwan Univ, Coll Med, Dept Internal Med, Taipei 10016, Taiwan Natl Taiwan Univ Taipei Taiwan 10016 Internal Med, Taipei 10016, Taiwan Natl Taiwan Univ, Coll Med, Dept Lab Med, Taipei 10016, Taiwan Natl TaiwanUniv Taipei Taiwan 10016 Dept Lab Med, Taipei 10016, Taiwan
Titolo Testata:
LIPIDS
fascicolo: 3, volume: 36, anno: 2001,
pagine: 237 - 245
SICI:
0024-4201(200103)36:3<237:PDLCIH>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-CELL COUNT; CORONARY HEART-DISEASE; RISK-FACTORS; ATHEROSCLEROSIS; FRAMINGHAM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Huang, ZS Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan S Rd, Taipei 10016,Taiwan Natl Taiwan Univ Hosp 7 Chung Shan S Rd Taipei Taiwan 10016 wan
Citazione:
Z.S. Huang et al., "Peripheral differential leukocyte counts in humans vary with hyperlipidemia, smoking, and body mass index", LIPIDS, 36(3), 2001, pp. 237-245

Abstract

Reports of diverse relationships between blood concentrations of differentlipids and peripheral total leukocyte count, and a unique lower peripheralmonocyte count in hypercholesterolemia, have driven us to think that in humans, peripheral differential leukocyte counts may be influenced differently by different types of hyperlipidemia. Our subjects were Taipei residents who attended a regular health check program in our hospital in 1998. A total of 3,282 subjects was enrolled, including 1,677 normolipidemic, 960 untreated borderline hyperlipidemic and 645 untreated hyperlipidemic subjects. By one-way analysis of variance (ANOVA), we found that different types of hyperlipidemia were associated with significant differences in differential leukocyte counts. In hypertriglyceridemia, the total leukocyte count and counts of all leukocyte subtypes were significantly higher than those in normolipidemia. Pure hypercholesterolemia, by contrast, was associated with a significantly lower monocyte count and no significant difference in other leukocyte counts. By two-way ANOVA adjusted for presence and degree of hyperlipidemia, we found significantly higher counts of total leukocytes and of all leukocyte subtypes in smokers, and significantly positive trends in relationships between body mass index (BMI) and counts of all leukocytes, neutrophils, lymphocytes, and monocytes. By multivariate regression analysis including all subjects, the serum triglyceride (TC) level was positively correlated with total leukocyte count and counts of all subtypes except eosinophils. On the contrary, serum high density lipoprotein-cholesterol had a negative correlation with total leukocyte count and with counts of neutrophils, monocytes, and basophils. In these multivariate regression analyses, there was no significant correlation between lipid levels and eosinophil count, whereas smoking was consistently associated with significantly higher countsof all leukocyte subtypes, including eosinophils. BMI had a significantly positive correlation with counts of all leukocytes, neutrophils, lymphocytes, and monocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 06:00:50