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Titolo:
Implementing a generic method development strategy for enantiomer analysis
Autore:
Chapman, J; Chen, FTA;
Indirizzi:
Beckman Coulter Inc, Fullerton, CA 92834 USA Beckman Coulter Inc Fullerton CA USA 92834 r Inc, Fullerton, CA 92834 USA
Titolo Testata:
LC GC NORTH AMERICA
fascicolo: 4, volume: 19, anno: 2001,
pagine: 427 - 431
SICI:
1527-5949(200104)19:4<427:IAGMDS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPILLARY-ELECTROPHORESIS; CHIRAL SELECTORS; SEPARATION; CYCLODEXTRINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Chapman, J Beckman Coulter Inc, 4300 N Harbor Blvd, Fullerton, CA 92834 USA Beckman Coulter Inc 4300 N Harbor Blvd Fullerton CA USA 92834 A
Citazione:
J. Chapman e F.T.A. Chen, "Implementing a generic method development strategy for enantiomer analysis", LC GC N AM, 19(4), 2001, pp. 427-431

Abstract

Drug discovery can involve screening natural products or synthesizing innovative new compounds, and the process can become more challenging with products that contain one or more chiral centers. These optically active compounds tend to make good drug candidates, however, so they require stereochemically selective assay methods for their analysis. In this article, the authors describe an enantiomer analysis method development strategy that uses afamily of highly sulfated cyclodextrins to resolve a diverse array of compounds. They propose this approach as a first step in developing methods forseparating enantiomers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 15:08:29