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Titolo:
Conditioning of skeletal muscles in adult and old mice for protection fromcontraction-induced injury
Autore:
Brooks, SV; Opiteck, JA; Faulkner, JA;
Indirizzi:
Univ Michigan, Inst Gerontol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 st Gerontol, Ann Arbor, MI 48109 USA Univ Michigan, Dept Physiol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Physiol, Ann Arbor, MI 48109 USA
Titolo Testata:
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
fascicolo: 4, volume: 56, anno: 2001,
pagine: B163 - B171
SICI:
1079-5006(200104)56:4<B163:COSMIA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIGITORUM LONGUS MUSCLES; CREATINE-KINASE ACTIVITY; RAT SOLEUS MUSCLE; ECCENTRIC EXERCISE; LENGTHENING CONTRACTIONS; REPEATED BOUTS; DAMAGE; FIBERS; BEHAVIOR; FORCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Brooks, SV Univ Michigan, Inst Gerontol, 300 N Ingalls,Room 961, Ann Arbor, MI 48109 USA Univ Michigan 300 N Ingalls,Room 961 Ann Arbor MI USA 48109 USA
Citazione:
S.V. Brooks et al., "Conditioning of skeletal muscles in adult and old mice for protection fromcontraction-induced injury", J GERONT A, 56(4), 2001, pp. B163-B171

Abstract

The purpose of this study was to design a conditioning program that protected muscles in both adult and old mice from a protocol of contractions thatpreviously caused a significant number of damaged fibers and a deficit in force, Hind-limb dorsiflexor muscles of adult (7 months) and old (22 months) female B6D2F1 mice were exposed once a week to a protocol of repeated forced stretches while maximally activated in vivo. By week 4, muscles of adult, but not old, mice showed no force deficit. Conditioning was continued for 6 weeks, when both age groups showed no force deficit for two consecutiveweeks. Three days after the sixth contraction protocol, when morphologicaldamage and force deficits are most severe, the numbers of damaged fibers in muscles of adult and old mice were not different from those in uninjured control muscles and the force deficits were reduced dramatically compared with unconditioned muscles. We conclude that muscles of both adult and old mice conditioned successfully, but muscles of old mice conditioned more slowly than those of adult mice.

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Documento generato il 30/03/20 alle ore 20:02:41