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Titolo:
A computational study of the effect of vasomotion on oxygen transport fromcapillary networks
Autore:
Goldman, D; Popel, AS;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 d Engn, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Ctr Computat Med & Biol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 & Biol, Baltimore, MD 21205 USA
Titolo Testata:
JOURNAL OF THEORETICAL BIOLOGY
fascicolo: 2, volume: 209, anno: 2001,
pagine: 189 - 199
SICI:
0022-5193(20010321)209:2<189:ACSOTE>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE MICROCIRCULATION; ARTERIOLAR VASOMOTION; BLOOD-FLOW; SPONTANEOUS FLUCTUATIONS; TISSUE; MYOGLOBIN; TORTUOSITY; SIMULATION; DIFFUSION; DELIVERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Goldman, D New Jersey Inst Technol, Dept Math Sci, Univ Hts, Newark, NJ 07102 USA New Jersey Inst Technol Univ Hts Newark NJ USA 07102 07102 USA
Citazione:
D. Goldman e A.S. Popel, "A computational study of the effect of vasomotion on oxygen transport fromcapillary networks", J THEOR BIO, 209(2), 2001, pp. 189-199

Abstract

The objective of this study was to investigate the effect of arteriolar vasomotion on oxygen transport from capillary networks. A computational modelwas used to calculate blood flow and oxygen transport from a simulated network of striated muscle capillaries. For varying tissue oxygen consumption rates, the importance of the Frequency and amplitude of vasomotion-induced blood Row oscillations was studied. The effect of myoglobin on oxygen delivery during vasomotion was also examined. In the absence of myoglobin, it was found that when consumption is high enough to produce regions of hypoxia under steady flow conditions, vasomotion-induced flow oscillations can significantly increase tissue oxygenation and decrease oxygen transport heterogeneity. The largest effect was seen for low-frequency, high-amplitude oscillations (1.5-3 cycles min(-1), 90% of steady-state velocity). By contrast, at physiological tissue myoglobin concentrations, vasomotion did not improve tissue oxygenation. This unexpected finding is due to the buffering effect of myoglobin, suggesting that in highly aerobic muscles short-term storage of oxygen is more important than the possibility of increasing transport through vasomotion. (C) 2001 Academic Press.

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Documento generato il 25/11/20 alle ore 06:24:53