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Titolo:
Role of platelet-activating factor in hepatectomy with Pringle's maneuver
Autore:
Gu, M; Takada, Y; Fukunaga, K; Ishiguro, S; Taniguchi, H; Seino, K; Yuzawa, K; Otsuka, M; Todoroki, T; Fukao, K;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Surg, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
JOURNAL OF SURGICAL RESEARCH
fascicolo: 2, volume: 96, anno: 2001,
pagine: 233 - 238
SICI:
0022-4804(200104)96:2<233:ROPFIH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA-REPERFUSION INJURY; HEPATIC INFLOW OCCLUSION; MAJOR LIVER RESECTION; RAT-LIVER; HEPATOCELLULAR-CARCINOMA; FACTOR ANTAGONIST; ENDOTHELIN-1; MANAGEMENT; PAF;
Keywords:
platelet-activating factor; hepatectomy; Pringle's maneuver; ischemia and reperfusion injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Takada, Y Univ Tsukuba, Inst Clin Med, Dept Surg, 1-1-1 Tennodai, Tsukuba,Ibaraki 3058575, Japan Univ Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki Japan 3058575 Japan
Citazione:
M. Gu et al., "Role of platelet-activating factor in hepatectomy with Pringle's maneuver", J SURG RES, 96(2), 2001, pp. 233-238

Abstract

Background. Interruption of hepatic inflow is commonly used to reduce blood loss during extensive liver resection, but may cause liver dysfunction, The present study investigated the effects of platelet-activating factor (PAF) antagonist E5880 on total liver warm ischemia and 70% hepatectomy. Methods. Rabbits were used in this study and were divided into four groups: group 1, those treated with only 70% hepatectomy; group 2, those treated with only 20 min Pringle's maneuver; group 3, those treated with both Pringle's maneuver and 70% hepatectomy without pretreatment; and group 4, those pretreated with PAF antagonist E5880 (0.3 mg/kg) followed by Pringle's maneuver and 70% hepatectomy. The remnant liver function was then evaluated after reperfusion. Results. Seven-day survival rates in both groups 1 and 2 were 100%, E5880 treatment significantly increased 7-day survival rate (group 4: 38% vs group 3: 0%, P < 0.05) after a combination of Pringle's maneuver and 10% hepatectomy. The elevations of serum liver enzymes (GOT, GPT, mGOT, and LDH) weresignificantly inhibited in group 4 at 1 and 4 h after reperfusion. Portal venous pressure and the energy charge of liver were also significantly improved in group 4, compared with those in group 3. Endothelin-1 levels of arterial and portal venous blood progressively increased after reperfusion; however, there were no significant differences between the two groups. Leukocyte infiltration into the liver was significantly inhibited in group 4. Conclusion. E5880 pretreatment has protective effects on liver function after 70% hepatectomy with Pringle's maneuver in rabbits. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 03:08:16