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Titolo:
Comparison of intradermal and subcutaneous injections in lymphatic mapping
Autore:
Kersey, TW; Van Eyk, J; Lannin, DR; Chua, AN; Tafra, L;
Indirizzi:
Anne Arundel Med Ctr, Breast Ctr, Annapolis, MD 21401 USA Anne Arundel MedCtr Annapolis MD USA 21401 Ctr, Annapolis, MD 21401 USA E Carolina Univ, Sch Med, Dept Surg, Greenville, NC 27858 USA E Carolina Univ Greenville NC USA 27858 pt Surg, Greenville, NC 27858 USA
Titolo Testata:
JOURNAL OF SURGICAL RESEARCH
fascicolo: 2, volume: 96, anno: 2001,
pagine: 255 - 259
SICI:
0022-4804(200104)96:2<255:COIASI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENTINEL-NODE BIOPSY; EARLY-STAGE MELANOMA; BREAST-CANCER; GAMMA-PROBE; BLUE-DYE; AXILLARY DISSECTION; CUTANEOUS MELANOMA; VULVAR CANCER; LYMPHOSCINTIGRAPHY; LYMPHADENECTOMY;
Keywords:
sentinel node biopsy; breast cancer; swine model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Kersey, TW Anne Arundel Med Ctr, Breast Ctr, 2001 Med Pkwy, Annapolis, MD 21401 USA Anne Arundel Med Ctr 2001 Med Pkwy Annapolis MD USA 21401 1 USA
Citazione:
T.W. Kersey et al., "Comparison of intradermal and subcutaneous injections in lymphatic mapping", J SURG RES, 96(2), 2001, pp. 255-259

Abstract

Background. Sentinel node biopsy (SNB) for melanoma, with its intradermal (ID) injection, has a higher success rate than SNB for breast cancer, whichis typically performed with a subcutaneous (SC) or peritumor injection. Itis hypothesized that this is in part due to a slower transit time of lymphatic mapping agents through the parenchymal lymphatics of the breast. No study has investigated differences in transit time between different tissues to account for this clinical observation. The goal of the study was to compare transit time between ID and SC injections: with common agents used in lymphatic mapping. Methods. Four injection sites on five domestic pigs were used. Sites were bilateral and included cervical, forelimb, hindlimb, and flank areas. Agents included technetium sulfur colloid (Tc99, filtered and unfiltered), isosulfan blue (IB) dye, and fluorescein (FL) dye. At each site both ID and SC injections were made and the transit time to reach the sentinel node was recorded. The transit time differences were calculated per centimeter distancefrom the draining lymph node basin. Results. Sentinel nodes were identified draining all sites and found to behot, blue, or fluorescent (using a Wood's lamp for identification). The cervical and forelimb injection sites drained to the same cervical lymph nodebasin and both SC and ID injection sites drained to the same sentinel node. Similarly, the hindlimb and flank injection sites both drained to inguinal lymph node basins. The slowest transit time occurred with Tc99 injected SC and the fastest occurred with Tc99 injected ID, whereas both FL dye and IB traveled rapidly to the sentinel node whether injected SC or ID. Large differences were found using unfiltered Tc99 depending on its injection ID (2.7 s/cm +/- 0.5) vs SC (249 s/cm +/- 14.7, P = 0.008). Conclusions. Tc99 ID injections were significantly faster than SC injection. The slowest and fastest SC injection agents were unfiltered Tc99 and IB,respectively. Dermal injections provide faster transit of lymphatic agentsand may improve the identification rate when applied to patients with breast cancer. (C) 2001 Academic Press

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:15:31