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Titolo:
Plasma homovanillic acid in untreated schizophrenia - relationship with symptomatology and sex
Autore:
Zhang, ZJ; Peet, M; Ramchand, CN; Shah, S; Reynolds, GP;
Indirizzi:
Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2TN S Yorkshire, England Univ Sheffield, No Gen Hosp, Dept Psychiat, Sheffield S5 7AU, S Yorkshire,England Univ Sheffield Sheffield S Yorkshire England S5 7AU , S Yorkshire,England SSG Hosp & Med Coll, Dept Psychiat, Baroda 390001, Gujarat, India SSG Hosp& Med Coll Baroda Gujarat India 390001 da 390001, Gujarat, India
Titolo Testata:
JOURNAL OF PSYCHIATRIC RESEARCH
fascicolo: 1, volume: 35, anno: 2001,
pagine: 23 - 28
SICI:
0022-3956(200101/02)35:1<23:PHAIUS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR ENLARGEMENT; NEGATIVE SYMPTOMS; DOPAMINE; METABOLISM; PSYCHOSIS; DEFICIT; INDEX; HVA;
Keywords:
plasma homovanillic acid; sex; schizophrenia; negative symptoms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Zhang, ZJ Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire,England Univ Sheffield Sheffield S Yorkshire England S10 2TN e, England
Citazione:
Z.J. Zhang et al., "Plasma homovanillic acid in untreated schizophrenia - relationship with symptomatology and sex", J PSYCH RES, 35(1), 2001, pp. 23-28

Abstract

Plasma homovanillic acid (pHVA) concentrations are considered to reflect. in part. central dopamine metabolism and thus may be of value in assessing the rule of dopamine neurotransmission in schizophrenia, Furthermore. some recent studies have suggested a relationship of pHVA with symptomatology. We have undertaken a study of pHVA in a large cohort of unmedicated DSM-IV schizophrenic patients in order to assess the relationship of pHVA to various clinical parameters, pHVA in 58 drug-free patients (10.11 +/-0.52 ng/ml) was significantly elevated in comparison with 62 matched control subjects (8.77 +/-0.39 ng/ml). pHVA was found to be higher in patients with a more negative syndrome. No significant correlation of pHVA with overall SAPS or SANS scores was apparent in the patients although, within the SANS subscales.a significant relationship to anhedonia-asociality was apparent. Interestingly, the male drug-free patients showed a correlation of pHVA with negative symptoms defined by SANS and several SANS subscales. while females showedno significant relationship with any SANS subscales. The results may suggest that an increased dopaminergic turnover is apparent in (male) schizophrenic patients with predominantly negative symptoms, providing some support for reports that this change in neuronal activity may be related to the neuropathological abnormalities seen in the disease, which may themselves differ between males and females. Such neuronal deficits of developmental or degenerative origin may thus result in an elevation/disinhibition of central dopamine metabolism in schizophrenia. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:28:14