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Titolo:
A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis
Autore:
Sigusch, B; Beier, M; Klinger, G; Pfister, W; Glockmann, E;
Indirizzi:
Univ Jena, Dept Periodontol, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 , Dept Periodontol, D-07740 Jena, Germany Univ Jena, Inst Med Microbiol, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 Inst Med Microbiol, D-07740 Jena, Germany
Titolo Testata:
JOURNAL OF PERIODONTOLOGY
fascicolo: 3, volume: 72, anno: 2001,
pagine: 275 - 283
SICI:
0022-3492(200103)72:3<275:A2NPAS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCALIZED JUVENILE PERIODONTITIS; ACTINOMYCETEMCOMITANS-ASSOCIATED PERIODONTITIS; ORAL ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; SEVERE GENERALIZED PERIODONTITIS; GRAM-NEGATIVE BACTERIA; BACTEROIDES-GINGIVALIS; REFRACTORY PERIODONTITIS; YOUNG-ADULTS; METRONIDAZOLE; THERAPY;
Keywords:
clindamycin/therapeutic use; doxycycline/therapeutic use; metronidazole/therapeutic use; periodontitis/drug therapy; planing; scaling; comparison study; follow-up studies; wound healing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Sigusch, B Univ Jena, Dept Periodontol, Bachstr 18, D-07740 Jena, Germany Univ Jena Bachstr 18 Jena Germany D-07740 -07740 Jena, Germany
Citazione:
B. Sigusch et al., "A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis", J PERIODONT, 72(3), 2001, pp. 275-283

Abstract

Background: In the last few years knowledge about periodontal infections has increased enormously, nevertheless practitioners are still seeking guidelines for suitable treatment concepts. Methods: The aim of this study was to examine the effect of doxycycline, metronidazole, and clindamycin used adjunctively in a 2-step non-surgical procedure in patients with rapidly progressive periodontitis (RPP). The firststep included scaling, root planing, and polishing (SRP) in each quadrant using 4 to 5 visits. The second step included full-mouth enhanced root planing (RP) and wound dressing in 1 or 2 visits after SRP and the beginning ofantibiotic therapy. Forty-eight patients (mean age 32.4 years) with generalized RPP, with an average of 16 sites with probing depths (PD) deeper than8 mm, and high counts of Porphyromonas gingivalis were randomly assigned to 4 different groups: group 1 (doxycycline) n = 12, group 2 (metronidazole)n = 15, group 3 (clindamycin) n = 11, and group 4 (control group; no antibiotic treatment) n = 10. Clinical evaluations, including plaque index (PI),sulcus bleeding index (SBI), probing depth (PD), clinical attachment level(CAL), and bacteriological and crevicular cell sampling, were done at baseline (BL), 3 weeks after SRP, and 6 and 24 months after RP. Results: After the first step (SRP), we observed an improvement of PI and SBI in all 4 groups, but did not see any statistically significant PD reduction 3 weeks after SRP compared to baseline. However, 6 and 24 months afterthe second step (RP) we observed a significantly greater reduction of PD in groups 2 and 3 and a significantly greater CAL gain in comparison to groups 1 and 4. After 24 months, the attachment level gain in group 1 and group4 was less than 1.5 mm, and less than 1.0 mm in PD site categories 6 to 9 mm and >9 mm. PI showed no significant difference between the groups throughout the period after SRP until 24 months, compared to 3 weeks after SRP SBI decreased most in the metronidazole and clindamycin groups. P. gingivalisand Actinobacillus actinomycetemcomitans were almost completely eradicatedin these 2 groups 24 months after RP In addition, the phagocytotic capacity of crevicular polymorphonuclear neutrophils was increased in groups 2 and3 after the second step. Conclusions: The present results show that metronidazole and clindamycin are effective antibiotics when used adjunctively in a 2-step non-surgical procedure of scaling and root planing in RPP patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:21:40