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Titolo:
Serum leptin, IGF-I and insulin levels in preterm infants receiving parenteral nutrition during the first week of life
Autore:
Park, MJ; Namgung, R; Kim, JN; Kim, DH;
Indirizzi:
Inje Univ, Sanggye Paik Hosp, Coll Med, Dept Pediat, Seoul 139707, South Korea Inje Univ Seoul South Korea 139707 ept Pediat, Seoul 139707, South Korea Miz Medi Hosp, Seoul, South Korea Miz Medi Hosp Seoul South KoreaMiz Medi Hosp, Seoul, South Korea Yonsei Univ, Coll Med, Dept Pediat, Seoul, South Korea Yonsei Univ SeoulSouth Korea Coll Med, Dept Pediat, Seoul, South Korea
Titolo Testata:
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
fascicolo: 4, volume: 14, anno: 2001,
pagine: 429 - 433
SICI:
0334-018X(200104)14:4<429:SLIAIL>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORD-BLOOD LEPTIN; PLASMA LEPTIN; GROWTH-FACTORS; BIRTH-WEIGHT; INTRAUTERINE GROWTH; FETAL GROWTH; OBESE GENE; OB/OB MICE; GAIN; NEWBORNS;
Keywords:
leptin; IGF-I; insulin; preterm infants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Park, MJ Inje Univ, Sanggye Paik Hosp, Coll Med, Dept Pediat, 210 Sanggye Dong, Seoul 139707, South Korea Inje Univ 210 Sanggye Dong Seoul South Korea 139707 South Korea
Citazione:
M.J. Park et al., "Serum leptin, IGF-I and insulin levels in preterm infants receiving parenteral nutrition during the first week of life", J PED END M, 14(4), 2001, pp. 429-433

Abstract

Leptin is involved in the regulation of body weight through a feedback signal between adipose tissue and the satiety center, to decrease food intake and increase energy expenditure. Newborn infants experience physiological weight loss during the first week of life. The leptin level may be decreasedto enhance food intake and to decrease energy expenditure for physiological adaptation during early postnatal days. Insulinlike growth factor-I (IGF-I) and insulin are involved in the regulation of perinatal growth. Leptin might be interrelated with IGF-I or insulin, since both of these have adipogenic and somatotropic effects. We therefore hypothesized that leptin, IGF-Iand insulin would be decreased during the first week of life, concurrentlywith physiological weight loss. Thirty preterm AGA infants (birth weight 1.574 +/- 313 g; GA 31.9 +/- 2.2 wk) were studied. All infants received parenteral nutrition from the third day after birth. Leptin was significantly decreased during the first week of life, and insulin was significantly increased at day 7 vs day 1 and day 3, IGF-I did not change during the first week of life, Leptin was positively correlated with body weight (r = 0.368, p <0.01), body mass index (r 0.267, p < 0.05), and serum IGF-I (r = 0.330, p < 0.01), but not with serum insulin. The percent of weight reduction duringthe first week of life was not correlated with the percent of leptin reduction during the first week of life. In conclusion, leptin was significantlydecreased and positively correlated with body weight and IGF-I during the first week of life, Changes of leptin and insulin might be related to postnatal adaptation in metabolism, but the exact role of leptin, IGF-I and insulin in postnatal physiological weight loss is not clear.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:44:31