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Titolo:
Efficacy of peripheral morphine analgesia in inflamed, non-inflamed and perineural tissue of dental surgery patients
Autore:
Likar, R; Koppert, W; Blatnig, H; Chiari, F; Sittl, R; Stein, C; Schafer, M;
Indirizzi:
LKH Klagenfurt, Abt Anaesthesiol & Intens Med, A-9020 Klagenfurt, Austria LKH Klagenfurt Klagenfurt Austria A-9020 Med, A-9020 Klagenfurt, Austria LKH Klagenfurt, Abt Mund Kiefer & Gesichtschirurg, A-9020 Klagenfurt, Austria LKH Klagenfurt Klagenfurt Austria A-9020 urg, A-9020 Klagenfurt, Austria Univ Erlangen Nurnberg, Inst Anesthesiol, D-8520 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-8520 D-8520 Erlangen, Germany Free Univ Berlin, Klin Anaesthesiol & Op Intens Med, D-1000 Berlin, Germany Free Univ Berlin Berlin Germany D-1000 ntens Med, D-1000 Berlin, Germany
Titolo Testata:
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
fascicolo: 4, volume: 21, anno: 2001,
pagine: 330 - 337
SICI:
0885-3924(200104)21:4<330:EOPMAI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPIOID RECEPTORS; INTRAARTICULAR MORPHINE; POSTOPERATIVE PAIN; INFLAMMATION; ANTINOCICEPTION; HYPERALGESIA; INVOLVEMENT; NEURONS;
Keywords:
morphine; dental surgery; perineural tissue;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Likar, R LKH Klagenfurt, Abt Anaesthesiol & Intens Med, St Veiter Str 47, A-9020 Klagenfurt, Austria LKH Klagenfurt St Veiter Str 47 Klagenfurt Austria A-9020 ustria
Citazione:
R. Likar et al., "Efficacy of peripheral morphine analgesia in inflamed, non-inflamed and perineural tissue of dental surgery patients", J PAIN SYMP, 21(4), 2001, pp. 330-337

Abstract

In a clinical model of dental pain, the analgesic efficacy of local morphine treatment was examined under three different conditions. Patients undergoing dental surgery were randomly assigned to an injection of local anesthetic articaine) plus 1 mg morphine either into inflamed (n = 14; trial I) ornon-inflamed (n = 24; trial 2) submucous tissue or perineurally n = 19 trial 3). Patients in the control group for each condition (n = 13 trial 1;n =26, trial 2;n = 16 trial 3) received articaine plus saline. Postoperative pain intensity was assessed by the visual analog scale (VAS) and numeric rating scale (NRS) at 0, 2, 4, 6, 8, 10, 12, 16, 20, and 24 h. In addition patients recorded the occurence of side effects and the supplemental consumption of diclofenac. Immediately after the operation pain scores were reducedto a similar. extent in all groups, most likely due to the local anesthetic effect. Thereafter pain scores and supplemental consumption of diclofenacwere significantly tower in patients receiving 1 mg morphine into inflamedsubmucous tissue than in the control group for up to 24 h. Patients receiving 1 mg morphine into non-inflamed tissue or perineurally did not show anyfurther reduction in pain scores compared to each control group. Our results show in patients undergoing dental surgery that injection of 1 mg of morphine into inflamed tissue results in significant and prolonged postoperative analgesia, whereas administration into non-inflamed tissue or perineurally is not effective. Thus, consistent with experimental studies, the requirement of an inflammatory process for the occurence of peripheral opioid effects is also found in the clinical setting (C) U.S. Cancer Pain Relief Committee, 2001.

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Documento generato il 03/07/20 alle ore 16:22:13