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Titolo:
Regional cerebral blood flow response to oral amphetamine challenge in healthy volunteers
Autore:
Devous, MD; Trivedi, MH; Rush, AJ;
Indirizzi:
Univ Texas, SW Med Ctr, Nucl Med Ctr, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 ed Ctr, Nucl Med Ctr, Dallas, TX 75235 USA Univ Texas, SW Med Ctr, Dept Radiol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Med Ctr, Dept Radiol, Dallas, TX 75235 USA Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 d Ctr, Dept Psychiat, Dallas, TX 75235 USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 4, volume: 42, anno: 2001,
pagine: 535 - 542
SICI:
0161-5505(200104)42:4<535:RCBFRT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; GLUCOSE-UTILIZATION; SCHIZOPHRENIC SUBJECTS; DEPRESSED-PATIENTS; NUCLEUS ACCUMBENS; BRAIN; DEXTROAMPHETAMINE; METABOLISM; DOPAMINE; SPECT;
Keywords:
amphetamine challenge; rCBF; SPECT; healthy volunteers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Devous, MD Univ Texas, SW Med Ctr, Nucl Med Ctr, 5323 Harry Hines Blvd, Dallas, TX 75235 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75235 75235 USA
Citazione:
M.D. Devous et al., "Regional cerebral blood flow response to oral amphetamine challenge in healthy volunteers", J NUCL MED, 42(4), 2001, pp. 535-542

Abstract

Functional brain imaging is a powerful tool for examining the central nervous system (CNS) response to pharmacologic challenges. Amphetamine is of interest both because of its role as a stimulant of the dopaminergic system and because of its use to alter mood in mood-disordered patients, particularly in patients suffering from depression. In this study, we report the effects of oral d-amphetamine relative to placebo on regional cerebral blood flow (rCBF) measured by SPECT in healthy volunteers to characterize the normal CNS response to this primarily dopaminergic stimulant. Methods: SPECT wasused to assess changes in rCBF induced by amphetamine in 16 healthy volunteers. Subjects received placebo and then 0.4 mg/kg oral amphetamine in a fixed-order single-blind design and were imaged on a triple-head tomograph. Another six healthy volunteers received placebo at both times to assess normal rCBF variability. rCBF changes were assessed with a three-dimensional voxel-based analysis integrated into an automated coregistration system. Datawere automatically normalized to whole-brain counts and coregistered, Resultant rCBF changes were evaluated parametrically through the formation of an image whose voxel values were based on the paired t statistic. Results: Amphetamine increased rCBF in two mesial prefrontal zones (Brodmann's areas 8 and 10), inferior orbital frontal robe (area 11), brain stem (ventral tegmentum), anteromesial temporal lobe (amygdala), and anterior thalamus. Amphetamine decreased rCBF to motor cortex, visual cortex, fusiform gyrus, posterolateral temporal robe, and right lateral temporal lobe. Conclusion: Our data suggest that amphetamine induces focal increases and decreases in rCBFin healthy volunteers in areas primarily innervated by dopamine pathways and in areas with secondary (primarily limbic) affiliations. These data are consistent with glucose metabolic data from autoradiographic studies in animals, in which the largest increases are seen in brain stem, followed by striatum, thalamus, and frontal and sensory cortices. Frontopolar and temporal increases observed in our study appear to be unique to humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 00:24:57