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Titolo:
Distinct K currents result in physiologically distinct cell types in the inferior colliculus of the rat
Autore:
Sivaramakrishnan, S; Oliver, DL;
Indirizzi:
Univ Connecticut, Ctr Hlth, Dept Neurosci, Farmington, CT 06030 USA Univ Connecticut Farmington CT USA 06030 urosci, Farmington, CT 06030 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 8, volume: 21, anno: 2001,
pagine: 2861 - 2877
SICI:
0270-6474(20010415)21:8<2861:DKCRIP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL COCHLEAR NUCLEUS; BINAURAL RESPONSE PROPERTIES; PATCH-CLAMP TECHNIQUES; VOLTAGE CLAMP; PHARMACOLOGICAL CHARACTERIZATION; DISCHARGE PATTERNS; NEURONS; CHANNELS; CONDUCTANCES; CHARYBDOTOXIN;
Keywords:
inferior colliculus; adaptation; rebound firing; high-threshold potassium current; Ca2+-dependent K+ current; charybdotoxin; apamin; A-current; Ca2+ spikes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Sivaramakrishnan, S Univ Connecticut, Ctr Hlth, Dept Neurosci, Farmington,CT 06030 USA Univ Connecticut Farmington CT USA 06030 CT 06030 USA
Citazione:
S. Sivaramakrishnan e D.L. Oliver, "Distinct K currents result in physiologically distinct cell types in the inferior colliculus of the rat", J NEUROSC, 21(8), 2001, pp. 2861-2877

Abstract

The inferior colliculus (IC) processes auditory information ascending fromthe brainstem. The response of the IC to this information and its ability to transform it is partly determined by the types of ionic currents that generate the intrinsic discharge patterns of IC neurons and their susceptibility to changes in the external environment. We have used whole-cell patch-clamp techniques on IC neurons in rat brain slices to characterize the potassium currents present and to correlate them with the firing patterns observed. Neurons in the IC can be classified into six physiologically distinct cell types. Each of these cell types has a firing pattern that is generated by a unique potassium current and set of cellular parameters. Sustained-regular cells show mainly delayed rectifier K+ channels. Onset cells have a unique high-threshold tetraethylammonium-sensitive K+ current. Pause-build cells have an A-current. Rebound-regular cells have calcium-dependent rebounddepolarizations. Rebound-adapting cells have both an apamin-sensitive calcium-dependent K+ current and a calcium-dependent rebound depolarization. Transient-rebound cells have a charybdotoxin-sensitive calcium-dependent K+ current and a calcium-dependent rebound. Our data suggest that there would be similarities as well as differences among IC neurons in their responses to excitatory or inhibitory inputs. Furthermore, some cells are likely to show little or no plasticity and behave as simple relays of temporal and intensity information, whereas others are likely to transform their inputs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 06:22:43