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Titolo:
Physiopathology and treatment of fatigue in multiple sclerosis
Autore:
Comi, G; Leocani, L; Rossi, P; Colombo, B;
Indirizzi:
Univ Milan, Sci Inst H San Raffaele, Dept Neurosci, I-20132 Milan, Italy Univ Milan Milan Italy I-20132 aele, Dept Neurosci, I-20132 Milan, Italy
Titolo Testata:
JOURNAL OF NEUROLOGY
fascicolo: 3, volume: 248, anno: 2001,
pagine: 174 - 179
SICI:
0340-5354(200103)248:3<174:PATOFI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOTOR EVOKED-POTENTIALS; NEUROLOGICAL DISORDERS; VOLUNTARY ACTIVATION; MUSCLE FATIGUE; THERAPY; AMANTADINE;
Keywords:
fatigue; multiple sclerosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Comi, G Univ Milan, Sci Inst H San Raffaele, Dept Neurosci, Via Olgettina 60, I-20132 Milan, Italy Univ Milan Via Olgettina 60 Milan Italy I-20132 0132 Milan, Italy
Citazione:
G. Comi et al., "Physiopathology and treatment of fatigue in multiple sclerosis", J NEUROL, 248(3), 2001, pp. 174-179

Abstract

Fatigue is a common symptom of patients with multiple sclerosis (MS). It is reported by about one-third of patients, and for many fatigue is the mostdisabling symptom. Fatigue may be associated with motor disturbances and/or mood disorders, which makes it very difficult to determine whether the fatigue is an aspect of these features or a result per se of the disease. Although peripheral mechanisms have some role in the pathogenesis of fatigue, in MS there are clear indications that the more important role is played by"central" abnormalities. Neurophysiological studies have shown that fatigue does not depend on involvement of the pyramidal tracts and implicate impairment of volitional drive of the descending motor pathways as a physiopathological mechanism. Metabolic abnormalities of the frontal cortex and basalganglia revealed by positron-emission tomography and correlations between fatigue and magnetic resonance imaging lesion burden support this hypothesis. Some recent studies also suggest that pro-inflammatory cytokines contribute to the sense of tiredness. No specific treatments are available. Management strategies include medications, exercise, and behavioural therapy; in most cases a combined approach is appropriate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:39:59