Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Enhancement of 3,4-methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonate
Autore:
Nixdorf, WL; Burrows, KB; Gudelsky, GA; Yamamoto, BK;
Indirizzi:
Univ Hosp Cleveland, Dept Psychiat, Program Basic & Clin Neurosci, Cleveland, OH 44106 USA Univ Hosp Cleveland Cleveland OH USA 44106 rosci, Cleveland, OH 44106 USA Univ Cincinnati, Coll Pharm, Cincinnati, OH 45221 USA Univ Cincinnati Cincinnati OH USA 45221 l Pharm, Cincinnati, OH 45221 USA
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 2, volume: 77, anno: 2001,
pagine: 647 - 654
SICI:
0022-3042(200104)77:2<647:EO3NBT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTITUTED AMPHETAMINES 3,4-METHYLENEDIOXYMETHAMPHETAMINE; SUCCINATE-DEHYDROGENASE INHIBITOR; KINASE-C PKC; RAT-BRAIN; SEROTONIN NEUROTOXICITY; INDUCED HYPERTHERMIA; BODY-TEMPERATURE; METHAMPHETAMINE NEUROTOXICITY; MEDIATED OXIDATION; MDMA;
Keywords:
malonate; MDMA; mitochondrial inhibition; microdialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamoto, BK Univ Hosp Cleveland, Dept Psychiat, Program Basic & Clin Neurosci, 11100 Euclid Ave, Cleveland, OH 44106 USA Univ Hosp Cleveland 11100 Euclid Ave Cleveland OH USA 44106 A
Citazione:
W.L. Nixdorf et al., "Enhancement of 3,4-methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonate", J NEUROCHEM, 77(2), 2001, pp. 647-654

Abstract

The acute and long-term effects of the local perfusion of 3,4-methylenedioxymethamphetamine (MDMA) and the interaction with the mitochondrial inhibitor malonate (MAL) were examined in the rat striatum. MDMA, MAL or the combination of MAL with MDMA was reverse dialyzed into the striatum for 8 h via a microdialysis probe while extracellular dopamine (DA) and serotonin (5-HT) were measured. One week later, tissue immediately surrounding the probe was assayed for DA and 5-HT tissue content. Local perfusion of MDMA increased DA and 5-HT release but did not produce long-term depletion of DA or 5-HTin tissue. Malonate also increased both DA and 5-HT release but, in contrast to MDMA, produced only longterm depletion of DA. The combined perfusion of MDMA/MAL synergistically increased the release of DA and 5-HT and produced long-term depletion of both DA and 5-HT in tissue. These results supportthe conclusion that DA, compared with 5-HT, neurons are more susceptible to mitochondrial inhibition. Moreover, MDMA, which does not normally produceDA depletion in the rat, exacerbated MAL-induced DA depletions. The effectof MDMA in combination with MAL to produce 5-HT depletion suggests a role for bin-energetic stress in MDMA-induced toxicity to 5-HT neurons. Overall,these results highlight the importance of energy balance to the function of DA and 5-HT neurons and to the toxic effects of MDMA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:21:38