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Titolo:
Stage-specific differential activation of mitogen-activated protein kinases in hypertrophied and failing rat hearts
Autore:
Hayashida, W; Kihara, Y; Yasaka, A; Inagaki, K; Iwanaga, Y; Sasayama, S;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 ovasc Med, Sakyo Ku, Kyoto 6068507, Japan
Titolo Testata:
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
fascicolo: 4, volume: 33, anno: 2001,
pagine: 733 - 744
SICI:
0022-2828(200104)33:4<733:SDAOMP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; LEFT-VENTRICULAR HYPERTROPHY; CULTURED CARDIAC MYOCYTES; MUSCLE CELL HYPERTROPHY; GENE-EXPRESSION; SIGNAL-TRANSDUCTION; PERFUSED HEART; MAP KINASES; II RECEPTOR; FAILURE;
Keywords:
angiotensin; signal transduction; heart failure; hypertrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Kihara, Y Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, 54 Shogoin Kawaharacho, Kyoto 6068507, Japan Kyoto Univ 54 Shogoin Kawaharacho Kyoto Japan 6068507 07, Japan
Citazione:
W. Hayashida et al., "Stage-specific differential activation of mitogen-activated protein kinases in hypertrophied and failing rat hearts", J MOL CEL C, 33(4), 2001, pp. 733-744

Abstract

Mitogen-activated protein kinases (MAPKs) are involved in the early development of cardiac hypertrophy, but their roles in chronic left ventricular hypertrophy (LVH) are unclear, We studied the angiotensin (Ang) II-induced cardiac MAPK activation of the hypertensive Dahl salt-sensitive (DS) rats inthe subacute developing LVH stage, the chronic compensated LVH stage, and the congestive heart failure (CHF) stage, In the isolated, coronary-perfused heart preparation, Ang II infusion (1 x 10(-6) mol/l) activated extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38-MAPK in the LV myocardium. No substantial differences were observed in the Ang II-induced ERK activation between the normotensive control DS rats and the hypertensive DS rats in either stage, In contrast, the Ang II-induced activation of JNK and p38-MAPK was augmented in the subacute LVH stage of thehypertensive DS rats, but then progressively attenuated in the chronic LVHand CHF stages, Chronic treatment with an angiotensin converting enzyme inhibitor, temocapril (20 mg/kg/day), ameliorated the responsiveness of the JNK/p38-MAPK activation, suggesting that the decreased JNK/p38-MAPK activation is a consequence of negative feedback; regulation for the activated cardiac renin-angiotensin system in chronic LVH and CHF. Thus, the Ang II-induced activation of multiple cardiac MAPK pathways are differentially regulated, depending on the stages of chronic hypertrophic process. The JNK and p38-MAPK activation may be involved in the early development of adaptive LVH. However, the responsiveness of the cardiac JNK/p38-MAPK pathways progressively decreased in chronic LVH and CHF under the chronic activation of tissuerenin-angiotensin system, (C) 2001 Academic Press.

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Documento generato il 07/04/20 alle ore 04:15:30