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Titolo:
Genetic association of an LBP-1c/CP2/LSF gene polymorphism with late onsetAlzheimer's disease
Autore:
Taylor, AE; Yip, A; Brayne, C; Easton, D; Evans, JG; Xuereb, J; Cairns, N; Esiri, MM; Rubinsztein, DC;
Indirizzi:
Addenbrookes Hosp, Dept Med Genet, Wellcome Trust Ctr Mol Mechanisms Dis, Cambridge Inst Med Res, Cambridge CB2 2XY, England Addenbrookes Hosp Cambridge England CB2 2XY , Cambridge CB2 2XY, England Addenbrookes NHS Trust, Dept Med Genet, Mol Genet Lab, Cambridge CB2 2QQ, England Addenbrookes NHS Trust Cambridge England CB2 2QQ bridge CB2 2QQ, England Univ Forvie Site, Dept Publ Hlth & Primary Care, Cambridge CB2 2SR, England Univ Forvie Site Cambridge England CB2 2SR e, Cambridge CB2 2SR, England Univ Cambridge, Dept Publ Hlth & Primary Care, CRC, Genet Epidemiol Unit,Strangeways Res Lab, Cambridge CB1 8RN, England Univ Cambridge Cambridge England CB1 8RN Lab, Cambridge CB1 8RN, England Radcliffe Infirm, Dept Clin Geratol, Oxford OX2 6HE, England Radcliffe Infirm Oxford England OX2 6HE Geratol, Oxford OX2 6HE, England Univ Cambridge, Addenbrookes Hosp, Dept Pathol, Cambridge CB2 2QQ, EnglandUniv Cambridge Cambridge England CB2 2QQ hol, Cambridge CB2 2QQ, England Inst Psychiat, Dept Neuropathol, MRC, Brain Bank, London SE5 8AF, England Inst Psychiat London England SE5 8AF Brain Bank, London SE5 8AF, England Radcliffe Infirm, Dept Neuropathol, Oxford OX2 6HE, England Radcliffe Infirm Oxford England OX2 6HE opathol, Oxford OX2 6HE, England
Titolo Testata:
JOURNAL OF MEDICAL GENETICS
fascicolo: 4, volume: 38, anno: 2001,
pagine: 232 - 233
SICI:
0022-2593(200104)38:4<232:GAOALG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
METAANALYSIS;
Keywords:
Alzheimer's disease; LBP-1c/CP2/LSF; dementia; MRC/CFAS study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Rubinsztein, DC Addenbrookes Hosp, Dept Med Genet, Wellcome Trust Ctr Mol Mechanisms Dis, Cambridge Inst Med Res, Wellcome MRC Bldg,Hills Rd, Cambridge CB2 2XY, England Addenbrookes Hosp Wellcome MRC Bldg,Hills Rd CambridgeEngland CB2 2XY
Citazione:
A.E. Taylor et al., "Genetic association of an LBP-1c/CP2/LSF gene polymorphism with late onsetAlzheimer's disease", J MED GENET, 38(4), 2001, pp. 232-233

Abstract

Objectives-The only locus unequivocally associated with late onset Alzheimer's disease (AD) risk is APOE. However, this locus accounts for less than half the genetic variance. A recent study suggested that the A allele of the 3'UTR biallelic polymorphism in the LBP-1clCP2lLSF gene was associated with reduced AD risk. Samples were diagnosed predominantly by clinical ratherthan pathological criteria. We have sought to replicate this finding in a series of necropsy confirmed, late onset AD cases and non-demented controls. Methods-The 3'UTR polymorphism in the LBP-1clCP2lLSF gene was typed in 216necropsy confirmed AD cases and 301 non-demented controls aged >73 years. Results-We found different LBP-1clCP2l LSF allele distributions in our AD cases and controls (p=0.048); the A allele was associated with reduced AD risk. The allele and genotype frequencies observed in our cases and controlswere similar to those previously reported. No significant effects emerged when the data were adjusted for age, sex, or apoE epsilon4 carrier status. Conclusions-Our data support LBP-1clCP2lLSF as a candidate gene/risk factor for AD and provide justification for future studies to investigate the role of this gene in Alzheimer's disease.

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Documento generato il 12/08/20 alle ore 21:01:44