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Titolo:
In vivo P-31 echo-planar spectroscopic imaging of human calf muscle
Autore:
Wilhelm, T; Bachert, P;
Indirizzi:
Deutsch Krebsforschungszentrum, Abt Biophys & Med Strahlenphys E0200, D-69120 Heidelberg, Germany Deutsch Krebsforschungszentrum Heidelberg GermanyD-69120 lberg, Germany
Titolo Testata:
JOURNAL OF MAGNETIC RESONANCE
fascicolo: 1, volume: 149, anno: 2001,
pagine: 126 - 130
SICI:
1090-7807(200103)149:1<126:IVPESI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN; CHEMICAL-SHIFT; INVIVO; NMR;
Keywords:
phosphorus NMR; echo-planar spectroscopic imaging; human calf muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Bachert, P Deutsch Krebsforschungszentrum, Abt Biophys & Med Strahlenphys E0200, Neuenheimer Feld 280, D-69120 Heidelberg, Germany Deutsch Krebsforschungszentrum Neuenheimer Feld 280 Heidelberg Germany D-69120
Citazione:
T. Wilhelm e P. Bachert, "In vivo P-31 echo-planar spectroscopic imaging of human calf muscle", J MAGN RES, 149(1), 2001, pp. 126-130

Abstract

Localized phosphorus-31 NMR spectra of human calf muscle in vivo were obtained by means of echo-planar spectroscopic imaging (EPSI) with a 1.5-T whole-body scanner. The technique permits the measurement of two-dimensional P-31 SI data at a minimum acquisition time of 2.4 s (8 x 8 voxels, TR = 300 ms). With 9.4 min measurement time (TR = 1100 ms, 64 averages) and 25 x 25 x40 mm spatial resolution in vivo the P-31 NMR signal-to-noise ratio (SIN) of the phosphocreatine (PCr) resonance was about 45; the multiplets of nucleoside 5'-triphosphates were resolved. Spectral quality permits quantitative assessment of the PCr signal in a measurement time that is shorter by a factor of 2 or more than the minimum measurement time feasible with chemical-shift imaging. In a functional EPSI study with a time resolution of 20.5 son the calf muscle of volunteers, spectra showed a 40% decrease of the PCrsignal intensity (at rest: S/N congruent to 12) upon exertion of the muscle. (C) 2001 Academic Press.

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Documento generato il 04/04/20 alle ore 08:56:44