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Titolo:
Differential effects of 15-deoxy-Delta(12,14)-prostaglandin J(2) and a peroxisome proliferator-activated receptor gamma agonist on macrophage activation
Autore:
Guyton, K; Bond, R; Reilly, C; Gilkeson, G; Halushka, P; Cook, J;
Indirizzi:
Med Univ S Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 nol, Charleston, SC 29425 USA Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 Med, Charleston, SC 29425 USA Med Univ S Carolina, Dept Pharmacol, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 col, Charleston, SC 29425 USA Med Univ S Carolina, Dept Physiol & Neurosci, Charleston, SC 29425 USA MedUniv S Carolina Charleston SC USA 29425 sci, Charleston, SC 29425 USA Univ S Carolina, Sch Med, Dept Pharmacol & Physiol, Charleston, SC 29425 USA Univ S Carolina Charleston SC USA 29425 Physiol, Charleston, SC 29425 USA
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 4, volume: 69, anno: 2001,
pagine: 631 - 638
SICI:
0741-5400(200104)69:4<631:DEO1JA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; TUMOR-NECROSIS-FACTOR; FACTOR-KAPPA-B; BACTERIAL LIPOPOLYSACCHARIDE; PROTEIN-KINASE; CYCLOPENTENONE PROSTAGLANDINS; PROSTANOID RECEPTORS; SIGNALING PATHWAYS; BIOLOGICAL-FLUIDS; PPAR-GAMMA;
Keywords:
BRL 49653; ERK 1/2; I kappa B alpha; NO; TNF-alpha; TxB2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Cook, J Med Univ S Carolina, Dept Microbiol & Immunol, 167 Ashley Ave,Suite 607, Charleston, SC 29425 USA Med Univ S Carolina 167 Ashley Ave,Suite 607 Charleston SC USA 29425
Citazione:
K. Guyton et al., "Differential effects of 15-deoxy-Delta(12,14)-prostaglandin J(2) and a peroxisome proliferator-activated receptor gamma agonist on macrophage activation", J LEUK BIOL, 69(4), 2001, pp. 631-638

Abstract

Prostaglandin J(2) metabolite 15-deoxy-Delta (12,14)-prostaglandin J(2) (15-PGJ(2)) appears to possess anti-inflammatory properties. Unlike other prostaglandins, it has Ilo known plasma membrane receptor. Its effects have been thought to occur through activation of the nuclear peroxisome proliferator-activated receptor gamma (PPAR gamma), hut 15-PGJ(2) map exhibit effectsindependent of PPAR gamma. We hypothesized that 15-PGJ(2) modulates macrophage (M phi) mediator production by acting on cell signaling proteins upstream of PPAR gamma. The effects of 15-PGJ(2) on bacterial endotoxin LPS-induced rat peritoneal M phi mediator production were compared with those of a specific PPAR gamma agonist, BRL 49653 (BRL), and to the eicosanoids prostaglandin D-2 (PGD(2)) and cicaprost (CICA, a prostacyclin analogue). 15-PGJ(2) inhibited LPS-induced production of NO, TNF-alpha, and thromboxane B-2 (TxB(2)). Equimolar concentrations of PGD2 and CICA significantly inhibited LPS-stimulated TNF-cx but not NO, and CICA increased TxB2 production. BRL inhibited LPS-induced NO, but augmented LPS-induced TNF-alpha and TxB(2). 15-PGJ(2) also inhibited degradation of LPS-induced I kappaB alpha and phosphoactivation of ERK 1/2, but BRL had no significant effect on either protein. The cyclopentenone ring 2-cyclopenten-1-one also inhibited LPS-induced ERK 1/2 activation; however, neither 15-PGJ(2) nor the cyclopentenone inhibited PMA-induced ERK 1/2 activation. Inhibition of LPS-stimulated mediator production by 15-PGJ(2) differed from inhibition by PGD(2), CICA, and BRL. The ability of 15-PGJ(2) to inhibit LPS-induced M phi mediator production andcell signaling may occur in part through reactivity of its cyclopentenone ring.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:35:41