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Titolo:
CD38 expression and functional activities are up-regulated by IFN-gamma onhuman monocytes and monocytic cell lines
Autore:
Musso, T; Deaglio, S; Franco, L; Calosso, L; Badolato, R; Garbarino, G; Dianzani, U; Malavasi, F;
Indirizzi:
Univ Turin, Dept Publ Hlth & Microbiol, I-10126 Turin, Italy Univ Turin Turin Italy I-10126 bl Hlth & Microbiol, I-10126 Turin, Italy Univ Turin, Dept Genet Biol & Biochem, Cell Biol Lab, I-10126 Turin, ItalyUniv Turin Turin Italy I-10126 chem, Cell Biol Lab, I-10126 Turin, Italy Univ Turin, Inst Internal Med, I-10126 Turin, Italy Univ Turin Turin Italy I-10126 , Inst Internal Med, I-10126 Turin, Italy Univ Naples Federico II, Biocrystallog Ctr, CNR, Naples, Italy Univ NaplesFederico II Naples Italy crystallog Ctr, CNR, Naples, Italy Inst G Gaslini, Genoa, Italy Inst G Gaslini Genoa ItalyInst G Gaslini, Genoa, Italy Univ Genoa, Dept Biochem, Genoa, Italy Univ Genoa Genoa ItalyUniv Genoa, Dept Biochem, Genoa, Italy Univ Brescia, Dept Pediat, Brescia, Italy Univ Brescia Brescia ItalyUniv Brescia, Dept Pediat, Brescia, Italy A Avogadro Univ Eastern Piedmont, Dept Med Sci, Novara, Italy A Avogadro Univ Eastern Piedmont Novara Italy pt Med Sci, Novara, Italy
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 4, volume: 69, anno: 2001,
pagine: 605 - 612
SICI:
0741-5400(200104)69:4<605:CEAFAA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADP-RIBOSYL CYCLASE; LYMPHOCYTE ANTIGEN CD38; TRANSENDOTHELIAL CHEMOTAXIS; ENDOTHELIAL-CELLS; INTERFERON-GAMMA; MESSENGER-RNA; RETINOIC ACID; B-CELLS; ACTIVATION; RECEPTOR;
Keywords:
cytokines; ADP-ribosyl cyclase; cADPR hydropase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Musso, T Univ Turin, Dept Publ Hlth & Microbiol, Via Santena 9, I-10126 Turin, Italy Univ Turin Via Santena 9 Turin Italy I-10126 -10126 Turin, Italy
Citazione:
T. Musso et al., "CD38 expression and functional activities are up-regulated by IFN-gamma onhuman monocytes and monocytic cell lines", J LEUK BIOL, 69(4), 2001, pp. 605-612

Abstract

Human CD38, a surface molecule expressed by immature and activated T and Blymphocytes, has been characterized as a molecule transducing activation and proliferation signals, and intervening in adhesion to endothelium via its ligand CD31, CD38 is also a complex ectoenzyme featuring ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase activities, leading to the synthesis and degradation of cADPR, a Ca+-mobilizing agent. We investigated the effects of monocyte-activating stimuli (IFR-gamma, IL-2, LPS, TNF-alpha, and GM-CSF) on the expression and function of CD38, starting from the observation that human monocytes and the derived lines U937, THP-1, and Mono-Mac-6 bear the molecule on their surface. Our results indicate that IFN-gamma is a strong up-modulator of CD38, and IL-2 increases its expression only modestly. LPS, TNF-cn, and GM-CSF had no detectable effects. Treatment with IFN-gamma produced a dose-and time-dependent up-regulation of CD38 in monocytes and monocytic lines, which was paralleled by increased ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase activities. Furthermore, CD38 ligation by specific MoAb reduced the IFN-gamma -dependent enhancement of monocyte-dynamic adhesion to endothelial monolayers. These findings identify IFN-gamma as a modulator of monocytic CD38 expression and indicate that CD38 plays a specific role in the activation and adhesion processes performed by monocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:26:12