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Titolo:
The collagenous domain of class A scavenger receptors is involved in macrophage adhesion to collagens
Autore:
Gowen, BB; Borg, TK; Ghaffar, A; Mayer, EP;
Indirizzi:
Univ S Carolina, Sch Med, Dept Microbiol & Immunol, Columbia, SC 29208 USAUniv S Carolina Columbia SC USA 29208 l & Immunol, Columbia, SC 29208 USA Univ S Carolina, Sch Med, Dept Dev Biol & Anat, Columbia, SC 29208 USA Univ S Carolina Columbia SC USA 29208 Biol & Anat, Columbia, SC 29208 USA
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 4, volume: 69, anno: 2001,
pagine: 575 - 582
SICI:
0741-5400(200104)69:4<575:TCDOCA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; ATHEROSCLEROTIC LESIONS; APOPTOTIC THYMOCYTES; LIGAND-BINDING; HOST-DEFENSE; CELLS; EXPRESSION; PROTEINS; MEDIATE; FAMILY;
Keywords:
artherogenesis; extracellular matrix; nonfibrillar; monoclonal antibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Mayer, EP Univ S Carolina, Sch Med, Dept Microbiol & Immunol, Columbia, SC29208 USA Univ S Carolina Columbia SC USA 29208 l, Columbia, SC 29208 USA
Citazione:
B.B. Gowen et al., "The collagenous domain of class A scavenger receptors is involved in macrophage adhesion to collagens", J LEUK BIOL, 69(4), 2001, pp. 575-582

Abstract

Class A macrophage scavenger receptors (MSRs) have a remarkably broad ligand specificity and are well-known for their roles in atherogenesis and hostdefense, Recently, we demonstrated that these receptors also recognize andmediate adhesion to denatured forms of type I collagen, In this study, theinvolvement of the collagenous domain of MSRs in binding to denatured typeI collagen was investigated. Transient expression of full-length, native type II MSR in COS-1 cells conferred adhesion to denatured type I collagens,whereas expression of a truncated receptor lacking the distal portion of the collagenous domain did not. Further, a synthetic peptide derived from the collagenous domain was effective in abrogating M phi adhesion to denatured forms of type I collagen, We also addressed collagen-type specificity by examining MSR affinity for type III and type IV collagens. As with type I collagen, M phis adhered only to denatured forms of type III collagen. Moreover, the adhesion was mediated by MSRs. m contrast, adhesion to denatured type IV collagen was not shown to be MSR-dependent, but adhesion to the native form was. MSR-mediated adhesion to types III and TV collagens was also shown to be dependent on the collagenous domain. Taken together, these data strongly suggest that the collagenous domain is involved in MSR-mediated adhesion to denatured forms of types I and III collagens and native, but not denatured, type IV collagen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 12:52:22