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Titolo:
The effects of extracellular pH on immune function
Autore:
Lardner, A;
Indirizzi:
Dublin Inst Technol, Dept Biol Sci, Dublin 8, Ireland Dublin Inst TechnolDublin Ireland 8 l, Dept Biol Sci, Dublin 8, Ireland
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 4, volume: 69, anno: 2001,
pagine: 522 - 530
SICI:
0741-5400(200104)69:4<522:TEOEPO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMORPHONUCLEAR LEUKOCYTE MEMBRANES; INTRACELLULAR PH; HUMAN-NEUTROPHILS; IN-VITRO; RESPIRATORY BURST; NA+/H+ EXCHANGE; LYMPHOCYTE-PROLIFERATION; METHYLMALONIC ACIDEMIA; TUMOR MICROENVIRONMENT; METABOLIC-ACIDOSIS;
Keywords:
immunity; acidosis; leukocytes; immunodeficiency; humoral; cellular;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Lardner, A Dublin Inst Technol, Dept Biol Sci, Kevin St, Dublin 8, IrelandDublin Inst Technol Kevin St Dublin Ireland 8 ublin 8, Ireland
Citazione:
A. Lardner, "The effects of extracellular pH on immune function", J LEUK BIOL, 69(4), 2001, pp. 522-530

Abstract

The effect of alterations in extracellular pH on cellular and humoral immune function is reviewed. Because acidic pH predominates at inflammatory loci and other sites of immune activity, most studies to date focus on the effect of acidic rather than alkaline pH, Investigations on polymorphonuclear leukocytes demonstrate mainly inhibition of chemotaxis, respiratory activity, and bactericidal capacity at reduced pH, Evidence of impaired lymphocytecytotoxicity and proliferation at acidic pH is also beginning to emerge. Many of the clinical acidoses are accompanied similarly by immunodeficiency. Studies on macrophages and eosinophils are few and inconclusive, A small number of studies demonstrate acid-induced activation of complement proteinsand the alternative complement pathway, plus increased antibody-binding toleukocytes at lowered pH, A differential effect of acidic pH on humoral and cellular immunity may, therefore, exist. Increasing recognition of the significance of extracellular pH in relation to immune function warrants further studies in this presently incomplete but rewarding field.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:29:15