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Titolo:
Substitution of an SSRI with bupropion sustained release following SSRI-induced sexual dysfunction
Autore:
Clayton, AH; McGarvey, EL; Abouesh, AI; Pinkerton, RC;
Indirizzi:
Univ Virginia, Dept Psychiat Med, Charlottesville, VA 22903 USA Univ Virginia Charlottesville VA USA 22903 Charlottesville, VA 22903 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
fascicolo: 3, volume: 62, anno: 2001,
pagine: 185 - 190
SICI:
0160-6689(200103)62:3<185:SOASWB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONING QUESTIONNAIRE CSFQ; OPEN TRIAL; SERTRALINE; DISCONTINUATION; VENLAFAXINE; OUTPATIENTS; DEPRESSION; PAROXETINE; YOHIMBINE; EFFICACY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Clayton, AH Univ Virginia, Dept Psychiat Med, 2955 Ivy Rd,Suite 210, Charlottesville, VA 22903 USA Univ Virginia 2955 Ivy Rd,Suite 210 Charlottesville VA USA 22903
Citazione:
A.H. Clayton et al., "Substitution of an SSRI with bupropion sustained release following SSRI-induced sexual dysfunction", J CLIN PSY, 62(3), 2001, pp. 185-190

Abstract

Background: We examine changes in sexual functioning and depressive symptoms in patients' transition from a selective serotonin reuptake inhibitor (SSRI), which induced both a therapeutic response and sexual dysfunction, to bupropion sustained release (SR) over the course of an 8-week trial. Method: The study included 11 adults (8 women and 3 men) who had a DSM-IV diagnosis of major depressive disorder in remission (Hamilton Rating Scale for Depression [HAM-D] score < 11)and were receiving an SSRI. Depression (using the HAM-D) and sexual dysfunction (using the Changes in Sexual Functioning Questionnaire) were assessed at baseline, 2 weeks after bupropion SR was added to the current antidepressant (combined treatment), 2 weeks after taper of the SSRI was initiated and completed, and after 4 weeks of bupropion SR monotherapy. T tests were performed to assess changes in depression and sexual function. Results: Patient participation dropped from the initial group of 11 at week 2 to 9 at week 4 and to 6 by week 8. Sexual functioning improved from week 0 (baseline) to week 2 and from week 2 to week 4. The patients showed no significant change in mean HAM-D scores in weekly comparisons during tile study period; 55% of patients completed the substitution without significantadverse events or recurrence of depressive symptoms. Conclusions Bupropion SR as a treatment for depression also alleviates sexual dysfunction due to SSRI treatment. Results show that sexual functioningimproves after the addition of bupropion SR to SSRI treatment and continues to improve, after discontinuation of the SSRI, with bupropion SR treatment alone.

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Documento generato il 19/01/20 alle ore 20:41:42