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Titolo:
Histamine release test and measurement oi antigen-specific IgE antibody inthe diagnosis of allergic conjunctival diseases
Autore:
Uchio, E; Matsuura, N; Matsumoto, S; Kadonosono, K; Ohno, S;
Indirizzi:
Yokohama City Univ, Dept Ophthalmol, Sch Med, Kanazawa Ku, Yokohama, Kanagawa 232, Japan Yokohama City Univ Yokohama Kanagawa Japan 232 ohama, Kanagawa 232, Japan
Titolo Testata:
JOURNAL OF CLINICAL LABORATORY ANALYSIS
fascicolo: 2, volume: 15, anno: 2001,
pagine: 71 - 75
SICI:
0887-8013(2001)15:2<71:HRTAMO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROVOCATION TEST; CHILDREN; RAST; HISTORY; ASTHMA; ASSAY; BLOOD;
Keywords:
histamine release test; allergic conjunctival diseases; CAP-RAST; allergic conjunctivitis; atopic keratoconjunctivitis; conjunctival provocation test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Uchio, E Yokohama City Univ, Med Ctr, Dept Ophthalmol, Minami Ku, 4-57 Urafune Cho,Yokohama, Kanagawa 2320024, Japan Yokohama City Univ 4-57 Urafune Cho Yokohama Kanagawa Japan 2320024
Citazione:
E. Uchio et al., "Histamine release test and measurement oi antigen-specific IgE antibody inthe diagnosis of allergic conjunctival diseases", J CL LAB AN, 15(2), 2001, pp. 71-75

Abstract

Although systemic allergic laboratory tests for the quantification of allergen-specific serum IgE antibody have been widely used, in these tests a high titer of serum specific IgE does not necessarily indicate evidence of allergy. We evaluated the diagnostic value of the glass microfiber-based histamine release test (HRT) using small amounts of whole blood, in 36 cases ofallergic conjunctival diseases: 17 cases of allergic conjunctivitis and 19of atopic keratoconjunctivitis. The patients were evaluated by HRT, capsulated hydrolic carrier polymer (CAP)-RAST, and conjunctival provocation test(CPT) against ten allergens. The positive rates for all allergens were higher in CAP-RAST than in HRT. The mean concordance of HRT with CAP-RAST results was 0.789. The mean concordance of HRT with CPT was 0.892 and that of CAP-RAST with CPT was 0.693. A significantly higher concordance was observedin HRT than CAP-RAST for Japanese cedar and mite antigen. The mean sensitivity, specificity, and efficiency of HRT were higher than those of CAP-RAST. These results indicate that CAP-RAST is good for the screening of allergens and that HRT has an advantage in the confirmation of clinical allergens in allergic conjunctival diseases because of its high sensitivity, specificity, efficiency, and higher concordance with CPT. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:30:51