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Titolo:
A reversible tracer analysis approach to the study of effective dopamine turnover
Autore:
Sossi, V; Doudet, DJ; Holden, JE;
Indirizzi:
Univ British Columbia, TRIUMF, Vancouver, BC V5Z 1M9, Canada Univ British Columbia Vancouver BC Canada V5Z 1M9 ver, BC V5Z 1M9, Canada Univ Wisconsin, Madison, WI USA Univ Wisconsin Madison WI USAUniv Wisconsin, Madison, WI USA
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 4, volume: 21, anno: 2001,
pagine: 469 - 476
SICI:
0271-678X(200104)21:4<469:ARTAAT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATECHOL-O-METHYLTRANSFERASE; POSITRON EMISSION TOMOGRAPHY; BRAIN TRANSFER CONSTANTS; TIME UPTAKE DATA; PARKINSONS-DISEASE; GRAPHICAL ANALYSIS; PET; REPRODUCIBILITY; INHIBITION;
Keywords:
dopaminergic system; effective dopamine turnover; distribution volume ratio; modeling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Sossi, V 4004 Wesbrook Mall, Vancouver, BC V6T 2A3, Canada 4004 Wesbrook Mall Vancouver BC Canada V6T 2A3 C V6T 2A3, Canada
Citazione:
V. Sossi et al., "A reversible tracer analysis approach to the study of effective dopamine turnover", J CEREBR B, 21(4), 2001, pp. 469-476

Abstract

Changes in dopamine turnover resulting from disease states such as Parkinson's disease may be reflected in corresponding changes in the kinetics of the positron emission tomographic tracer [F-18]fluorodopa. The authors had previously refined the conventional irreversible-tracer graphical approach to determine both the uptake rate constant Ki and the rate constant k(loss) that describes the slow loss of the trapped kinetic component. Because these parameters change in the opposite sense with disease, their ratios may bemore powerfully discriminating than either one alone. The ratio k(loss)/K-i is indicative of effective dopamine turnover. Its inverse, K-i/k(loss), can be interpreted as the effective distribution volume (EDV) of the specific uptake compartment referred to the fluorodopa concentration in plasma. Here the authors present a new approach to the estimation of EDV based on reversible-tracer graphical methods. When implemented with a plasma input function, the method evaluates EDV directly. When implemented with a tissue input function, the outcome is proportional to the ratio of the distribution volumes of the specific uptake and precursor compartments. Comparison of thenew and previous approaches strongly validates this alternative approach to the study of effective dopamine turnover.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:19:41