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Titolo:
Phosphoinositides in membrane traffic at the synapse
Autore:
Cremona, O; De Camilli, P;
Indirizzi:
Univ Piemonte Orientale A Avogadro, Dept Med Sci, I-28100 Novara, Italy Univ Piemonte Orientale A Avogadro Novara Italy I-28100 00 Novara, Italy Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA Yale Univ NewHaven CT USA 06510 Dept Cell Biol, New Haven, CT 06510 USA Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 Hughes Med Inst, New Haven, CT 06510 USA
Titolo Testata:
JOURNAL OF CELL SCIENCE
fascicolo: 6, volume: 114, anno: 2001,
pagine: 1041 - 1052
SICI:
0021-9533(200103)114:6<1041:PIMTAT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE; GUANINE-NUCLEOTIDE-EXCHANGE; ADP-RIBOSYLATION FACTOR; RECEPTOR-MEDIATED ENDOCYTOSIS; CLATHRIN-COATED VESICLES; CULTURED HIPPOCAMPAL-NEURONS; PLECKSTRIN HOMOLOGY DOMAIN; ASSEMBLY PROTEIN AP-2; HIGH-AFFINITY BINDING; PHOSPHOLIPASE-D;
Keywords:
phosphoinositide; synaptic vesicle; neurotransmitter release; clathrin-mediated endocytosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
172
Recensione:
Indirizzi per estratti:
Indirizzo: Cremona, O Univ Piemonte Orientale A Avogadro, Dept Med Sci, Via Solaroli 17, I-28100Novara, Italy Univ Piemonte Orientale A Avogadro Via Solaroli 17Novara Italy I-28100
Citazione:
O. Cremona e P. De Camilli, "Phosphoinositides in membrane traffic at the synapse", J CELL SCI, 114(6), 2001, pp. 1041-1052

Abstract

Inositol phospholipids represent a minor fraction of membrane phospholipids; yet they play important regulatory functions in signaling pathways and membrane traffic, The phosphorylated inositol ring can act either as a precursor for soluble intracellular messengers or as a binding site for cytosolic or membrane proteins. Hence, phosphorylation-dephosphorylation of phosphoinositides represents a mechanism for regulation of recruitment to the membrane of coat proteins, cytoskeletal scaffolds or signaling complexes and for the regulation of membrane proteins. Recent work suggests that phosphoinositide metabolism has an important role in membrane traffic at the synapse. PtdIns(4,5)P-2 generation is implicated in the secretion of at least a subset of neurotransmitters. Furthermore, PtdIns(4,5)P-2 plays a role in the nucleation of clathrin coats and of an actin-based cytoskeletal scaffold at endocytic zones of synapses, and PtdIns(4,5)P-2 dephosphorylation accompanies the release of newly formed vesicles from these interactions. Thus, the reversible phosphorylation of inositol phospholipids may be one of the mechanisms governing the timing and vectorial progression of synaptic vesicle membranes during their exocytic-endocytic cycle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 11:25:02