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Titolo:
The bactericidal effect and chemical reactions of acidified nitrite under conditions simulating the stomach
Autore:
Xu, J; Xu, X; Verstraete, W;
Indirizzi:
State Univ Ghent, Lab Microbial Ecol & Technol, B-9000 Ghent, Belgium State Univ Ghent Ghent Belgium B-9000 l & Technol, B-9000 Ghent, Belgium
Titolo Testata:
JOURNAL OF APPLIED MICROBIOLOGY
fascicolo: 4, volume: 90, anno: 2001,
pagine: 523 - 529
SICI:
1364-5072(200104)90:4<523:TBEACR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-NITROSO COMPOUNDS; DIETARY NITRATE; GASTROINTESTINAL-TRACT; LISTERIA-MONOCYTOGENES; ESCHERICHIA-COLI; HUMAN-SALIVA; OXIDE; LACTOBACILLUS; CIRCULATION; TOLERANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Verstraete, W State Univ Ghent, Lab Microbial Ecol & Technol, Coupure Links 653, B-9000 Ghent, Belgium State Univ Ghent Coupure Links 653 Ghent Belgium B-9000 ium
Citazione:
J. Xu et al., "The bactericidal effect and chemical reactions of acidified nitrite under conditions simulating the stomach", J APPL MICR, 90(4), 2001, pp. 523-529

Abstract

Aims: To examine the hypothesis of non-immune defence mechanisms based on nitrite. Methods and Results: The acidified media (nutrient broth or citrate-phosphate buffer) under aerobic conditions with additions of physiological levelsof nitrite, L-ascorbic acid, iodide and thiocyanate were used to simulate gastric juice. The bactericidal effects of acidified nitrite on Escherichiacoli and lactobacilli were investigated using bacterial plate counts. Conversion of acidified nitrite to nitric oxide, nitrogen dioxide and nitrate was also studied. Nitrite significantly increased the bactericidal effects on E. coli and lactobacilli. The bactericidal effects were enhanced by thiocyanate but not by L-ascorbic acid and iodide. L-Ascorbic acid and thiocyanate, but not iodide, enhanced the decomposition of acidified nitrite in nutrient broth. Acidified nitrite was converted to both nitric oxide and nitrate, but a portion of the acidified nitrite in nutrient broth may have been converted to other unidentified nitrogen compounds. Nitrogen dioxide was notdetected in any of the samples. Conclusions: The bactericidal effects of nitrite appeared to be primarily related to nitrous acid, and possibly to other unidentified nitrogenous metabolites, but not to nitric oxide and nitrogen dioxide. Significance and Impact of the Study: The potential role of nitrite as an antimicrobial substance in the stomach may be of some importance in the ecology of the gastrointestinal tract and in host physiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:07:28