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Titolo:
Depression in late life, cognitive decline and white matter pathology in two clinico-pathologically investigated cases
Autore:
Lloyd, AJ; Grace, JB; Jaros, E; Peny, RH; Fairbairn, AF; Swann, AG; OBrien, JT; McKeith, IG;
Indirizzi:
Newcastle Gen Hosp, Wolfson Res Ctr, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England Newcastle Gen Hosp Newcastle Upon Tyne Tyne & Wear England NE4 6BE ngland Newcastle Gen Hosp, Dept Neuropathol, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England Newcastle Gen Hosp Newcastle Upon Tyne Tyne & Wear England NE4 6BE ngland Newcastle Gen Hosp, Castleside Unit, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England Newcastle Gen Hosp Newcastle Upon Tyne Tyne & Wear England NE4 6BE ngland
Titolo Testata:
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
fascicolo: 3, volume: 16, anno: 2001,
pagine: 281 - 287
SICI:
0885-6230(200103)16:3<281:DILLCD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MRI SIGNAL HYPERINTENSITIES; GERIATRIC DEPRESSION; ALZHEIMERS-DISEASE; SUBCORTICAL HYPERINTENSITIES; VASCULAR DEPRESSION; ELDERLY PATIENTS; MOOD DISORDERS; FOLLOW-UP; RESONANCE; LESIONS;
Keywords:
cognitive impairment; depression; neuroimaging; neuropathology; treatment resistance; vascular disease; white matter lesions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Lloyd, AJ Royal Victoria Infirm, Dept Psychiat, Queen Victoria Rd, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England Royal Victoria Infirm Queen Victoria Rd Newcastle Upon Tyne Tyne & Wear England NE1 4LP
Citazione:
A.J. Lloyd et al., "Depression in late life, cognitive decline and white matter pathology in two clinico-pathologically investigated cases", INT J GER P, 16(3), 2001, pp. 281-287

Abstract

Case reports We report two cases of late life depression who became progressively more resistant to treatment, developed cognitive impairment, and began to exhibit neurological abnormalities and evidence of vascular disease. A discussion of the clinical features of the cases is accompanied by reports of neuropathology and neuroimaging findings. Extensive white matter lesions were present on computed tomography in both patients, and based gangliainfarcts were seen in one. Neuropathology revealed evidence of cerebral atrophy, demyelination and white matter lesions in addition to cerebrovascular and generalised vascular disease. Neither patient exhibited Alzheimer pathology outwith the norm for their age. We believe this to be the first report of neuropathological findings in depression with white matter changes. Literature review The pathological basis of white matter lesions and theirrelationship to depression, its age of onset and clinical features is addressed in relation to the cases described. Pathological investigation of white matter lesions has not previously been carried out in depression and hypotheses regarding their nature in this illness are based on extrapolation from research in a variety of other disorders. The association of depressionwith vascular risk factors is considered, as is the relationship between depression and cognitive deficits. There is a need for further investigationin this area. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:56:52