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Titolo:
Decreased expression of signaling lymphocytic-activation molecule-associated protein (SAP) transcripts in T cells from patients with rheumatoid arthritis
Autore:
Takei, M; Ishiwata, T; Mitamura, K; Fujiwara, S; Sasaki, K; Nishi, T; Kuga, T; Ookubo, T; Horie, T; Ryu, J; Ohi, H; Sawada, S;
Indirizzi:
Nihon Univ, Sch Med, Dept Internal Med 1, Tokyo 1738610, Japan Nihon UnivTokyo Japan 1738610 Dept Internal Med 1, Tokyo 1738610, Japan Nihon Univ, Sch Med, Dept Microbiol, Tokyo 1738610, Japan Nihon Univ Tokyo Japan 1738610 Med, Dept Microbiol, Tokyo 1738610, Japan Nihon Univ, Sch Med, Dept Orthoped Surg, Tokyo 1738610, Japan Nihon Univ Tokyo Japan 1738610 Dept Orthoped Surg, Tokyo 1738610, Japan Nihon Univ, Sch Med, Dept Internal Med 2, Tokyo 1738610, Japan Nihon UnivTokyo Japan 1738610 Dept Internal Med 2, Tokyo 1738610, Japan Nihon Univ, Neirima Hikarigaoka Nihon Univ Hosp, Sch Med, Tokyo 1738610, Japan Nihon Univ Tokyo Japan 1738610 Univ Hosp, Sch Med, Tokyo 1738610, Japan Kyowa Hakko Kogyo Co Ltd, Tokyo Res Labs, Machida, Tokyo 1948533, Japan Kyowa Hakko Kogyo Co Ltd Machida Tokyo Japan 1948533 Tokyo 1948533, Japan
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 4, volume: 13, anno: 2001,
pagine: 559 - 565
SICI:
0953-8178(200104)13:4<559:DEOSLM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; LINKED LYMPHOPROLIFERATIVE-DISEASE; NATURAL-KILLER-CELLS; INFECTED B-CELLS; SYNOVIAL MEMBRANES; NUCLEAR ANTIGEN; NASOPHARYNGEAL CARCINOMA; REVISED CRITERIA; ENCODING GENE; 2B4;
Keywords:
molecular biology; mRNA; rheumatoid arthritis; T lymphocyte;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Sawada, S Nihon Univ, Sch Med, Dept Internal Med 1, 30-1 Oyaguchi Itabashi, Tokyo 1738610, Japan Nihon Univ 30-1 Oyaguchi Itabashi Tokyo Japan 1738610 10, Japan
Citazione:
M. Takei et al., "Decreased expression of signaling lymphocytic-activation molecule-associated protein (SAP) transcripts in T cells from patients with rheumatoid arthritis", INT IMMUNOL, 13(4), 2001, pp. 559-565

Abstract

The function of Epstein-Barr virus (EBV)-specific cytotoxic T cells is disturbed in rheumatoid arthritis (RA) patients but the mechanism for this disturbance has remained unknown. In a recent study searching for the causative gene of X-linked lymphoproliferative syndrome, the gene possibly linked to EBV-specific cytotoxic T cells or NK cell-mediated cytotoxic activity to EBV-infected cells was discovered, and its product is now referred to as signaling lymphocytic-activation molecule-associated protein (SAP) or Src homology 2 domain-containing protein (SH2D1A), In the present study, we attempted to investigate the involvement of the SAP gene in RA using a quantitative real-time PCR; the expression level of SAP transcripts in peripheral leukocytes or T cells was examined for patients with PA. The expression level of SAP transcripts in peripheral leukocytes of 21 RA patients was significantly lower than that of 13 normal individuals (P = 0.0007), four patients with palindromic RA, 11 with inactive systemic lupus erythematosus (SLE) or 17 with chronic renal diseases. The decreased expression of SAP transcriptsin RA patients was also observed in peripheral CD2(+) T cells compared with normal individuals. There was no mutation in the coding region of SAP cDNAs derived from peripheral leukocytes of five RA patients. The decreased expression of SAP transcripts in peripheral leukocytes or T cells of RA patients might lead to the failure of the immune system to eliminate the EBV-infected synovial lining cells in joints of RA patients. Our findings have suggested that decreased expression of the SAP gene might be Involved in the onset or progress of RA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:08:59