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Titolo:
Longitudinal analysis of T cells responding to tetanus toroid in healthy subjects as well as in pediatric patients after bone marrow transplantation:the identification of identical TCR-CDR3 regions in time suggests long-term stability of at least part of the antigen-specific TCR repertoire
Autore:
Godthelp, BC; van Tol, MJD; Vossen, JM; van den Elsen, PJ;
Indirizzi:
Leiden Univ, Med Ctr, Dept Pediat, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Leiden Univ, Med Ctr, Dept Immunohaematol, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Leiden Univ, Med Ctr, Dept Blood Transfus, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 4, volume: 13, anno: 2001,
pagine: 507 - 518
SICI:
0953-8178(200104)13:4<507:LAOTCR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN BASIC-PROTEIN; V-GENE SEGMENTS; MHC CLASS-II; PERIPHERAL-BLOOD; IN-VIVO; NEUROTRANSMITTER RELEASE; IMMUNE RECONSTITUTION; MULTIPLE-SCLEROSIS; MONOZYGOTIC TWINS; CLONAL EXPANSION;
Keywords:
clonal expansion; human; repertoire development; T lymphocytes; TCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: van den Elsen, PJ Leiden Univ, Med Ctr, Dept Pediat, Bldg 1,E3-Q,POB 9600,NL-2300 RC Leiden, Netherlands Leiden Univ Bldg 1,E3-Q,POB 9600 Leiden Netherlands NL-2300 RC
Citazione:
B.C. Godthelp et al., "Longitudinal analysis of T cells responding to tetanus toroid in healthy subjects as well as in pediatric patients after bone marrow transplantation:the identification of identical TCR-CDR3 regions in time suggests long-term stability of at least part of the antigen-specific TCR repertoire", INT IMMUNOL, 13(4), 2001, pp. 507-518

Abstract

To understand the nature of long-term Th immune responses, we investigatedin the present study the TCRBV gene repertoire of CD4(+) T cells specific for the recall antigen tetanus toroid (TT) in recipients of an allogeneic bone marrow transplantation (allo-BMT) at several time points after transplantation and in their BM donors. We observed that the TCR repertoire of TT-specific CD4(+) Th cells was heterogeneous, and differed between allo-BMT recipients and their respective donors. Some individuals, however, used similar TCR-complementarity-determining region (CDR)3 motifs that could reflect recognition of and selection by similar promiscuous epitopes of TT. Longitudinal analysis of this TT-specific T cell response revealed that T cells with completely identical TCR were present at several time points after the first analysis in allo-BMT recipients, most probably reflecting long-term stability of at least part of the antigen-specific TCR repertoire. Similar stability of the TT-specific TCR repertoire in time was also noted in the allo-BMT donors. These observations reveal that within a given individual the dominant antigen-specific T cell clones persist in time in an otherwise diverse TT-specific CD4(+) T cell immune response.

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Documento generato il 04/04/20 alle ore 11:52:27