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Titolo:
Cloning of a catalytic subunit of cAMP-dependent protein kinase from the honeybee (Apis mellifera) and its localization in the brain
Autore:
Eisenhardt, D; Fiala, A; Braun, P; Rosenboom, H; Kress, H; Ebert, PR; Menzel, R;
Indirizzi:
Free Univ Berlin, Inst Biol Neurobiol, D-14195 Berlin, Germany Free Univ Berlin Berlin Germany D-14195 urobiol, D-14195 Berlin, Germany Free Univ Berlin, Inst Biol Genet, D-14195 Berlin, Germany Free Univ Berlin Berlin Germany D-14195 l Genet, D-14195 Berlin, Germany Univ Queensland, Dept Biochem, St Lucia, Qld 4072, Australia Univ Queensland St Lucia Qld Australia 4072 St Lucia, Qld 4072, Australia
Titolo Testata:
INSECT MOLECULAR BIOLOGY
fascicolo: 2, volume: 10, anno: 2001,
pagine: 173 - 181
SICI:
0962-1075(200104)10:2<173:COACSO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM-MEMORY; MUSHROOM BODIES; PREFERENTIAL EXPRESSION; BEE BRAIN; REGULATORY SUBUNIT; DROSOPHILA; GENE; BODY; RECEPTOR; MUTATIONS;
Keywords:
honeybee; PKA; learning; brain; mushroom body;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Eisenhardt, D Free Univ Berlin, Inst Biol Neurobiol, Koenigin Luise Str 28-30, D-14195 Berlin, Germany Free Univ Berlin Koenigin Luise Str 28-30 Berlin Germany D-14195
Citazione:
D. Eisenhardt et al., "Cloning of a catalytic subunit of cAMP-dependent protein kinase from the honeybee (Apis mellifera) and its localization in the brain", INSEC MOL B, 10(2), 2001, pp. 173-181

Abstract

In the honeybee the cAMP-dependent signal transduction cascade has been implicated in processes underlying learning and memory, The cAMP-dependent protein kinase (PKA) is the major mediator of cAMP action. To characterize the PKA system in the honeybee brain we cloned a homologue of a PKA catalyticsubunit from the honeybee,The deduced amino acid sequence shows 80-94% identity with catalytic subunits of PKA from Drosophila melanogaster, Aplysia californica and mammals. The corresponding gene is predominantly expressed in the mushroom bodies, a structure that is involved in learning and memoryprocesses. However, expression can also be found in the antennal and opticlobes,The level of expression varies within all three neuropiles.

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Documento generato il 04/04/20 alle ore 14:29:43