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Titolo:
Myelopathy in a previously asymptomatic HIV-1-infected patient
Autore:
Eyer-Silva, WA; Auto, I; Pinto, JFC; Morais-de-Sa, CA;
Indirizzi:
Univ Fed Rio de Janeiro, Dept Clin Immunol, Hosp Univ Gaffree & Guinle, BR-20270004 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-20270004 BCeiro, Brazil
Titolo Testata:
INFECTION
fascicolo: 2, volume: 29, anno: 2001,
pagine: 99 - 102
SICI:
0300-8126(200103/04)29:2<99:MIAPAH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; AIDS-ASSOCIATED MYELOPATHY; VACUOLAR MYELOPATHY; INFECTION; HIV-1; HTLV; MYOCLONUS;
Keywords:
antiretroviral therapy; HIV-1 infection; myelopathy; myelitis; spinal cord disorders;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Eyer-Silva, WA Univ Fed Rio de Janeiro, Dept Clin Immunol, Hosp Univ Gaffree & Guinle, Rua Mariz & Barros 775, BR-20270004 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rua Mariz & Barros 775 Rio De Janeiro Brazil BR-20270004 BC
Citazione:
W.A. Eyer-Silva et al., "Myelopathy in a previously asymptomatic HIV-1-infected patient", INFECTION, 29(2), 2001, pp. 99-102

Abstract

A wide variety of disorders of diverse pathogenic mechanisms can trigger spinal cord dysfunction in HIV-1-infected patients. The most common such condition is HIV-1-associated myelopathy (HM) which characteristically complicates advanced HIV-1 disease in patients with Low CD4 cell counts and previous AIDS-defining diagnoses, We describe an unusual presentation of HM in a previously asymptomatic patient with a relatively preserved CD4 cell count (458 cells/mm(3)) who was even unaware of his serological status. The patient presented with a clinically severe, slowly progressive myelopathy and could not walk unassisted. Significant neurological improvement could be obtained as rapidly as within 4 weeks after the institution of an antiretroviral combination of only two nucleoside analog HIV-1 reverse transcriptase inhibitors (zidovudine and didanosine). An HIV-1 protease inhibitor was also prescribed at that point but could only be added to intensify the regimen 3 months Later, when significant neurological improvement had already been recorded, We also review the disorders reported to derange spinal cord function in previously asymptomatic HIV-1-infected patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:15:08